Recombinant Human CCL5/RANTES Protein | R&D Systems 278-RN product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CCL5/RANTES Protein

catalog :

278-RN

quantity :

10 ug (also 50 ug)

price :

199 USD

citations: 52

Reference
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Bott A, Erdem N, Lerrer S, Hotz Wagenblatt A, Breunig C, Abnaof K, et al. miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A. Oncotarget. 2017;8:43897-43914 pubmed publisher
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Jin Q, Chen H, Wang X, Zhao L, Xu Q, Wang H, et al. The Effects of the Recombinant CCR5 T4 Lysozyme Fusion Protein on HIV-1 Infection. PLoS ONE. 2015;10:e0131894 pubmed publisher
Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman B, et al. The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. PLoS Pathog. 2013;9:e1003852 pubmed publisher
Chen Z, Kim S, Chamberlain N, Pickens S, Volin M, Volkov S, et al. The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis. J Immunol. 2013;190:5256-66 pubmed publisher
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Alonzo F, Kozhaya L, Rawlings S, Reyes Robles T, Dumont A, Myszka D, et al. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature. 2013;493:51-5 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Badr G, Lefevre E, Mohany M. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS ONE. 2011;6:e23741 pubmed publisher
Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, et al. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J Immunol. 2011;186:5254-60 pubmed publisher
Reeves E, Williamson M, Byrne B, Bergin D, Smith S, Greally P, et al. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol. 2010;184:1642-52 pubmed publisher
Barroso González J, El Jaber Vazdekis N, García Expósito L, Machado J, Zarate R, Ravelo A, et al. The lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities. J Biol Chem. 2009;284:16609-20 pubmed publisher
Eyman D, Damodarasamy M, Plymate S, Reed M. CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis. J Cell Physiol. 2009;220:376-81 pubmed publisher
Osei Kumah A, Smith R, Clifton V. Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Cytokine. 2008;43:187-93 pubmed publisher
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Gonzalez R, Seurynck Servoss S, Crowley S, Brown M, Omenn G, Hayes D, et al. Development and validation of sandwich ELISA microarrays with minimal assay interference. J Proteome Res. 2008;7:2406-14 pubmed publisher
Biancotto A, Iglehart S, Lisco A, Vanpouille C, Grivel J, Lurain N, et al. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res Hum Retroviruses. 2008;24:453-62 pubmed publisher
Nobile C, Lind M, Miro F, Chemin K, Tourret M, Occhipinti G, et al. Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes. Blood. 2008;111:3579-90 pubmed publisher
Anogianaki A, Castellani M, Madhappan B, Salini V, Vecchiet J, Tete S, et al. RANTES (CCL5) potentiates calcium ionophore in the production of LTB4 in rat adherent macrophages from granuloma induced by KMnO4: inhibiton by NDGA. Pharmacol Res. 2008;57:49-55 pubmed
Qui H, Ferrell E, Nolan N, Phelps B, Tabibiazar R, Whitney D, et al. Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin Chem. 2007;53:2010-2 pubmed
Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, et al. Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int J Cancer. 2008;122:769-76 pubmed
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product information

brand :

R&D Systems

master code :

278-RN

SKU :

278-RN-010

product name :

Recombinant Human CCL5/RANTES Protein

description :

The Recombinant Human CCL5/RANTES Protein from R&D Systems is derived from E. coli.

target :

CCL5/RANTES

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

7.8 kDa

gene symbol :

CCL5

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR5. The ED50 for this effect is 1-5 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

278-RN

accessionNumbers :

P13501

source :

E. coli -derived human CCL5/RANTES protein Ser24-Ser91

2020 USD :

199

2021 USD :

199 USD

alt names :

chemokine (C-C motif) ligand 5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SISd, SIS-delta, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.