product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human MFG-E8 Protein, CF
catalog :
2767-MF-050
quantity :
50 ug
price :
408 USD
more info or order :
R&D Systems product webpage
citations: 23
Reference
Urban L, Nov xe1 k x, x10c oma M, Dvo x159 xe1 nkov xe1 B, Lacina L, x160 xe1 chov xe1 J, et al. Unravelling heterogeneous effects of cancer‑associated fibroblasts on poor prognosis markers in breast cancer EM‑G3 cell line: In vitro‑targeted treatment (anti‑IL-6, anti‑VEGF-A, anti‑MFGE8) based on tr. Oncol Rep. 2024;51: pubmed publisher
Tabasum S, Thapa D, Giobbie Hurder A, Weirather J, Campisi M, Schol P, et al. EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade. Cancer Immunol Res. 2023;11:1493-1507 pubmed publisher
Chaung W, Zhang F, Ma G, Yen H, Jacob A, Brenner M, et al. Development of human cell-expressed tag-free rhMFG-E8 as a radiation mitigator and a therapeutic for acute kidney injury. Res Sq. 2023;: pubmed publisher
Cui Y, Luo L, Zeng Z, Liu X, Li T, He X, et al. MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells. Cell Death Dis. 2023;14:2 pubmed publisher
Marazuela P, Solé M, Bonaterra Pastra A, Pizarro J, Camacho J, Martínez Sáez E, et al. MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy. Acta Neuropathol Commun. 2021;9:154 pubmed publisher
Han K, Singh K, Rodman M, Hassanzadeh S, Baumer Y, Huffstutler R, et al. Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. Nutrients. 2021;13: pubmed publisher
Shi Z, Wang Q, Zhang Y, Jiang D. Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model. Stem Cell Res Ther. 2020;11:253 pubmed publisher
Kanzaki Y, Fujita H, Sato K, Hosokawa M, Matsumae H, Shiraga F, et al. KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci. 2020;61:38 pubmed publisher
Chiang H, Chu P, Lee T. MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells. J Biomed Sci. 2019;26:61 pubmed publisher
Pan Z, Dumas E, Lawrence C, Pate L, Longobardi S, Wang X, et al. Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling. Int J Mol Sci. 2019;20: pubmed publisher
Gao Y, Zhang Z, Zhuang Z, Lu Y, Wu L, Ye Z, et al. Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin ?3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury. Cell Death Dis. 2018;9:845 pubmed publisher
Calton M, Beaulieu M, Benchorin G, Vollrath D. Method for measuring extracellular flux from intact polarized epithelial monolayers. Mol Vis. 2018;24:425-433 pubmed
Nakashima Y, Miyagi Shiohira C, Noguchi H, Omasa T. Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells. Mol Ther. 2018;26:1715-1734 pubmed publisher
Inana G, Murat C, An W, Yao X, Harris I, Cao J. RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. J Transl Med. 2018;16:63 pubmed publisher
Müller C, Charniga C, Temple S, Finnemann S. Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium. Stem Cell Reports. 2018;10:1075-1087 pubmed publisher
Zhao Q, Xu L, Sun X, Zhang K, Shen H, Tian Y, et al. MFG-E8 overexpression promotes colorectal cancer progression via AKT/MMPs signalling. Tumour Biol. 2017;39:1010428317707881 pubmed publisher
Nakai W, Yoshida T, Diez D, Miyatake Y, Nishibu T, Imawaka N, et al. A novel affinity-based method for the isolation of highly purified extracellular vesicles. Sci Rep. 2016;6:33935 pubmed publisher
Heo K, Cushman H, Akaike M, Woo C, Wang X, Qiu X, et al. ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis. Circulation. 2014;130:180-91 pubmed publisher
Abe T, Shin J, Hosur K, Udey M, Chavakis T, Hajishengallis G. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8. J Immunol. 2014;193:1383-91 pubmed publisher
Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V. Neutrophil microparticles modulate cytokine production by natural killer cells. Cytokine. 2014;65:126-9 pubmed publisher
Lankry D, Rovis T, Jonjic S, Mandelboim O. The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells. Eur J Immunol. 2013;43:2151-61 pubmed publisher
Lin Y, Hsu M, Chiou Y, Hsu H, Tsai H, Peng Y, et al. Comparative proteomic analysis of rat aorta in a subtotal nephrectomy model. Proteomics. 2010;10:2429-43 pubmed publisher
Tóth B, Garabuczi E, Sarang Z, Vereb G, Vámosi G, Aeschlimann D, et al. Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells. J Immunol. 2009;182:2084-92 pubmed publisher
product information
brand :
R&D Systems
master code :
2767-MF
SKU :
2767-MF-050
product name :
Recombinant Human MFG-E8 Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human MFG-E8 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MFG-E8 Protein, CF has been validated for the following applications: Bioactivity.
target :
MFG-E8
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in NaH2PO4 and NaCl.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
40-58 kDa, reducing conditions
theoretical molecular weight :
41.6 kDa
gene symbol :
MFGE8
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of SVEC4-10 mouse vascular endothelial cells. When 5 x 104 cells/well are added to Recombinant Human MFG-E8 coated plates (10 ╡g/mL, 100 ╡L/well), approximately 45-75% will adhere after 60 minutes at 37 ░C.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q08431.2
applications :
Bioactivity
source :
NS0-derived Recombinant Human MFG-E8 Protein, CF
USD :
408 USD
alt names :
BA46, Breast epithelial antigen BA46, EDIL1, hP47, HsT19888, lactadherin, Lactahedrin, Medin, MFG1, MFGE8, MFG-E8, MFGM, Milk fat globule-EGF factor 8, milk fat globule-EGF factor 8 protein, O-acetyl disialoganglioside synthase, OAcGD3S, SED1, SPAG10, sperm associated antigen 10, sperm surface protein hP47
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.