Recombinant Human CXCL2/GRO beta Protein | R&D Systems 276-GB-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CXCL2/GRO beta Protein

catalog :

276-GB-010

quantity :

10 ug (also 50 ug)

price :

249 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Su V, Chen W, Yu W, Wu H, Chen H, Yang K. Nintedanib Regulates GRK2 and CXCR2 to Reduce Neutrophil Recruitment in Endotoxin-Induced Lung Injury. Int J Mol Sci. 2021;22: pubmed publisher
Cheng A, Yang K, Chen N, Hsu T, Jou R, Hsieh S, et al. CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra. PLoS ONE. 2017;12:e0186780 pubmed publisher
Sukkurwala A, Martins I, Wang Y, Schlemmer F, Ruckenstuhl C, Durchschlag M, et al. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Cell Death Differ. 2014;21:59-68 pubmed publisher
Laarman A, Mijnheer G, Mootz J, van Rooijen W, Ruyken M, Malone C, et al. Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. EMBO J. 2012;31:3607-19 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Fan X, Patera A, Pong Kennedy A, Deno G, Gonsiorek W, Manfra D, et al. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J Biol Chem. 2007;282:11658-66 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

276-GB

SKU :

276-GB-010

product name :

Recombinant Human CXCL2/GRO beta Protein

Description :

The Recombinant Human CXCL2/GRO beta Protein from R&D Systems is derived from E. coli. The Recombinant Human CXCL2/GRO beta Protein has been validated for the following applications: Bioactivity.

target :

CXCL2/GRO beta/MIP-2/CINC-3

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

8 kDa

gene symbol :

CXCL2

details of functionality :

Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. et al . (1987) J. Immunol. 139 :3474. The ED50 for this effect is 0.3-0.9 µg/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is 3-15 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_002080

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CXCL2/GRO beta Protein

USD :

249 USD

alt names :

chemokine (C-X-C motif) ligand 2, CINC-2a, CINC3, CINC-3, C-X-C Motif Chemokine 2, GRO beta, GRO2, GRO2 oncogene, GROb, Gro-beta, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, melanoma growth stimulatory activity beta, MGSA beta, MGSA-b, MGSA-beta, MIP2, MIP-2, MIP-2a, MIP2A, MIP2-alpha, SCYB2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage