Recombinant Human CXCL1/GRO alpha Protein | R&D Systems 275-GR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CXCL1/GRO alpha Protein

catalog :

275-GR

quantity :

10 ug (also 50 ug)

price :

199 USD

citations: 23

Reference
Björkman L, Christenson K, Davidsson L, Mårtensson J, Amirbeagi F, Welin A, et al. Neutrophil recruitment to inflamed joints can occur without cellular priming. J Leukoc Biol. 2019;105:1123-1130 pubmed publisher
Werner Klein M, Scheitler S, Hoffmann M, Hodak I, Dietz K, Lehnert P, et al. Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nat Commun. 2018;9:595 pubmed publisher
Kim E, Moon S, Kim D, Zhang X, Kim J. CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma. PLoS ONE. 2018;13:e0188847 pubmed publisher
Schludi B, Moin A, Montemurro C, Gurlo T, Matveyenko A, Kirakossian D, et al. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017;2: pubmed publisher
MikuÅ‚a Pietrasik J, Uruski P, SosiÅ„ska P, Maksin K, Piotrowska Kempisty H, KuciÅ„ska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
Hosseini H, Obradović M, Hoffmann M, Harper K, Sosa M, Werner Klein M, et al. Early dissemination seeds metastasis in breast cancer. Nature. 2016;540:552-558 pubmed publisher
Wang H, Hong L, Huang J, Jiang Q, Tao R, Tan C, et al. P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res. 2015;25:674-90 pubmed publisher
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFÎ±-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher
Jung J, Lee S, Kim J, Lee S, Sung H, An J, et al. CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev. 2015;24:948-61 pubmed publisher
Anderson J, Titz B, Akiyama R, Komisopoulou E, Park A, Tap W, et al. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res. 2014;12:1740-54 pubmed publisher
Dong Y, Kabir S, Lee E, Son D. CXCR2-driven ovarian cancer progression involves upregulation of proinflammatory chemokines by potentiating NF-?B activation via EGFR-transactivated Akt signaling. PLoS ONE. 2013;8:e83789 pubmed publisher
Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, et al. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood. 2014;123:239-48 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Reikvam H, Hatfield K, Oyan A, Kalland K, Kittang A, Bruserud O. Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur J Haematol. 2010;84:239-51 pubmed publisher
Wu F, Wang Q, Zhang Z, Huang S, Yuan W, Liu J, et al. Identifying serological biomarkers of hepatocellular carcinoma using surface-enhanced laser desorption/ionization-time-of-flight mass spectroscopy. Cancer Lett. 2009;279:163-70 pubmed publisher
Begley L, Kasina S, MacDonald J, Macoska J. The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. Cytokine. 2008;43:194-9 pubmed publisher
Yang H, Cohen P, Rousseau S. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell Signal. 2008;20:375-80 pubmed
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, et al. S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell. 2008;19:78-85 pubmed
Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, et al. Novel antiviral activity of chemokines. Virology. 2006;350:484-92 pubmed
Nguyen A, Stebbins E, Henson M, O Young G, Choi S, Quon D, et al. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp Cell Res. 2006;312:1909-23 pubmed
Mihara K, Smit M, Krajnc Franken M, Gossen J, Rooseboom M, Dokter W. Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur J Immunol. 2005;35:2573-82 pubmed
Traves S, Smith S, Barnes P, Donnelly L. Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. J Leukoc Biol. 2004;76:441-50 pubmed
Keane M, Donnelly S, Belperio J, Goodman R, Dy M, Burdick M, et al. Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J Immunol. 2002;169:6515-21 pubmed

product information

brand :

R&D Systems

master code :

275-GR

SKU :

275-GR-010

product name :

Recombinant Human CXCL1/GRO alpha Protein

description :

The Recombinant Human CXCL1/GRO alpha Protein from R&D Systems is derived from E. coli. The Recombinant Human CXCL1/GRO alpha Protein has been validated for the following applications: Bioactivity.

target :

CXCL1/GRO alpha/KC/CINC-1

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

7.9 kDa

gene symbol :

CXCL1

details of functionality :

Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. et al . (1987) J. Immunol. 139 :3474. The ED50 for this effect is 0.15-0.3 µg/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is 1-4 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

275-GR

accessionNumbers :

P09341

applications :

Bioactivity

source :

E. coli -derived human CXCL1/GRO alpha/KC/CINC-1 protein Ala35-Asn107

2020 USD :

199

2021 USD :

199 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.