Recombinant Human CXCL1/GRO alpha Protein | R&D Systems 275-GR-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CXCL1/GRO alpha Protein

catalog :

275-GR-010

quantity :

10 ug (also 50 ug)

price :

249 USD

more info or order :

R&D Systems product webpage

citations: 29

Reference
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Gnosa S, Puig Blasco L, Piotrowski K, Freiberg M, Savickas S, Madsen D, et al. ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion. JCI Insight. 2022;7: pubmed publisher
Conod A, Silvano M, Ruiz i Altaba A. On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm. Cell Rep. 2022;38:110490 pubmed publisher
Roy R, Zayas J, Singh S, Delgado K, Wood S, Mohamed M, et al. Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound. elife. 2022;11: pubmed publisher
Kwon J, Kim M, Um S, Lee H, Bae Y, Choi S, et al. Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling. Cells. 2021;10: pubmed publisher
Bornemann L, Schuster M, Schmitz S, Sobczak C, Bessen C, Merz S, et al. Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib. BMC Cancer. 2020;20:650 pubmed publisher
Björkman L, Christenson K, Davidsson L, Mårtensson J, Amirbeagi F, Welin A, et al. Neutrophil recruitment to inflamed joints can occur without cellular priming. J Leukoc Biol. 2019;105:1123-1130 pubmed publisher
Werner Klein M, Scheitler S, Hoffmann M, Hodak I, Dietz K, Lehnert P, et al. Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nat Commun. 2018;9:595 pubmed publisher
Kim E, Moon S, Kim D, Zhang X, Kim J. CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma. PLoS ONE. 2018;13:e0188847 pubmed publisher
Schludi B, Moin A, Montemurro C, Gurlo T, Matveyenko A, Kirakossian D, et al. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017;2: pubmed publisher
MikuÅ‚a Pietrasik J, Uruski P, SosiÅ„ska P, Maksin K, Piotrowska Kempisty H, KuciÅ„ska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
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Wang H, Hong L, Huang J, Jiang Q, Tao R, Tan C, et al. P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res. 2015;25:674-90 pubmed publisher
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFÎ±-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher
Jung J, Lee S, Kim J, Lee S, Sung H, An J, et al. CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev. 2015;24:948-61 pubmed publisher
Anderson J, Titz B, Akiyama R, Komisopoulou E, Park A, Tap W, et al. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res. 2014;12:1740-54 pubmed publisher
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Begley L, Kasina S, MacDonald J, Macoska J. The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. Cytokine. 2008;43:194-9 pubmed publisher
Yang H, Cohen P, Rousseau S. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell Signal. 2008;20:375-80 pubmed
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image

image 1 :

Recombinant Human CXCL1/GRO alpha Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

275-GR

SKU :

275-GR-010

product name :

Recombinant Human CXCL1/GRO alpha Protein

Description :

The Recombinant Human CXCL1/GRO alpha Protein from R&D Systems is derived from E. coli. The Recombinant Human CXCL1/GRO alpha Protein has been validated for the following applications: Bioactivity.

target :

CXCL1/GRO alpha/KC/CINC-1

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

7.9 kDa

gene symbol :

CXCL1

details of functionality :

Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. et al . (1987) J. Immunol. 139 :3474. The ED50 for this effect is 0.15-0.3 µg/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is 1-4 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P09341

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CXCL1/GRO alpha Protein

USD :

249 USD

alt names :

CINC1, CINC-1, FSP, GRO alpha, GRO1, GROa, KC, MGSA, MGSA-a, MGSA-alpha, NAP-3, SCYB1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage