Recombinant Human CCL1/I-309 Protein | R&D Systems 272-I-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CCL1/I-309 Protein

catalog :

272-I-010

quantity :

10 ug (also 50 ug)

price :

237 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Haque N, Tuteja A, Haque N. CC chemokine CCL1 receptor CCR8 mediates conversion of mesenchymal stem cells to embryoid bodies expressing FOXP3+CCR8+ regulatory T cells. PLoS ONE. 2019;14:e0218944 pubmed publisher
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, et al. CCR8+FOXp3+ Treg cells as master drivers of immune regulation. Proc Natl Acad Sci U S A. 2017;114:6086-6091 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Islam S, Chang D, Colvin R, Byrne M, McCully M, Moser B, et al. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol. 2011;12:167-77 pubmed publisher
Montes Vizuet R, Vega Miranda A, Valencia Maqueda E, Negrete García M, Velásquez J, Teran L. CC chemokine ligand 1 is released into the airways of atopic asthmatics. Eur Respir J. 2006;28:59-67 pubmed
Ruffini P, Biragyn A, Coscia M, Harvey L, Cha S, Bogen B, et al. Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxis. J Leukoc Biol. 2004;76:77-85 pubmed
Huber T, Reinhardt H, Exner M, Burger J, Kerjaschki D, Saleem M, et al. Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol. 2002;168:6244-52 pubmed
Cashman J, Clark Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 2002;99:792-9 pubmed
Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, et al. A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J Leukoc Biol. 2001;70:617-23 pubmed

product information

brand :

R&D Systems

master code :

272-I

SKU :

272-I-010

product name :

Recombinant Human CCL1/I-309 Protein

description :

The Recombinant Human CCL1/I-309 Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL1/I-309 Protein has been validated for the following applications: Bioactivity.

target :

CCL1/I-309/TCA-3

category :

Proteins and Enzymes

unit sizes :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

8.5 kDa

gene symbol :

CCL1

details of functionality :

Measured by its ability to chemoattract BW5147 mouse T lymphoma cells. The ED50 for this effect is 3-9 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR8. The ED50 for this effect is 1.5-7.5 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P22362.1

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CCL1/I-309 Protein

USD :

237 USD

alt names :

C-C motif chemokine 1, chemokine (C-C motif) ligand 1, I-309, inflammatory cytokine I-309, P500, SCYA1, SCYA1Small-inducible cytokine A1, SCYA2, SISe, small inducible cytokine A1 (I-309, homologous to mouse Tca-3), T lymphocyte-secreted protein I-309, TCA3, TCA-3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage