This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human CCL3/MIP-1 alpha Protein
catalog :
270-LD
quantity :
10 ug (also 50 ug)
price :
249 USD
citations: 34
Reference |
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Qui H, Ferrell E, Nolan N, Phelps B, Tabibiazar R, Whitney D, et al. Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin Chem. 2007;53:2010-2 pubmed
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Pfleger C, Schloot N, ter Veld F. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J Immunol Methods. 2008;329:214-8 pubmed
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Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, et al. Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int J Cancer. 2008;122:769-76 pubmed
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Grivel J, Elliott J, Lisco A, Biancotto A, Condack C, Shattock R, et al. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS. 2007;21:1263-72 pubmed
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Jang S, Kim Y, Kim Y, Sung H, Ko J. Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. J Biol Chem. 2007;282:11092-100 pubmed
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Biancotto A, Grivel J, Iglehart S, Vanpouille C, Lisco A, Sieg S, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007;109:4272-9 pubmed
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Whittall T, Wang Y, Younson J, Kelly C, Bergmeier L, Peters B, et al. Interaction between the CCR5 chemokine receptors and microbial HSP70. Eur J Immunol. 2006;36:2304-14 pubmed
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Masih Khan E, Trudel S, Heise C, Li Z, Paterson J, Nadeem V, et al. MIP-1alpha (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma. Blood. 2006;108:3465-71 pubmed
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Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, et al. Novel antiviral activity of chemokines. Virology. 2006;350:484-92 pubmed
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Dioszeghy V, Benlhassan Chahour K, Delache B, Dereuddre Bosquet N, Aubenque C, Gras G, et al. Changes in soluble factor-mediated CD8+ cell-derived antiviral activity in cynomolgus macaques infected with simian immunodeficiency virus SIVmac251: relationship to biological markers of progression. J Virol. 2006;80:236-45 pubmed
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Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
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Tay S, McCormack A, Rose M. Effect of cognate human CD4+ T cell and endothelial cell interactions upon chemokine production. Transplantation. 2004;78:987-94 pubmed
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Chang W, Baumgarth N, Yu D, Barry P. Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J Virol. 2004;78:8720-31 pubmed
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Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
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Banisadr G, Queraud Lesaux F, Boutterin M, Pelaprat D, Zalc B, Rostene W, et al. Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain. J Neurochem. 2002;81:257-69 pubmed
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Lehner T, Wang Y, Doyle C, Tao L, Bergmeier L, Mitchell E, et al. Induction of inhibitory antibodies to the CCR5 chemokine receptor and their complementary role in preventing SIV infection in macaques. Eur J Immunol. 1999;29:2427-35 pubmed
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product information
brand :
R&D Systems
master code :
270-LD
SKU :
270-LD-010
product name :
Recombinant Human CCL3/MIP-1 alpha Protein
description :
The Recombinant Human CCL3/MIP-1 alpha Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL3/MIP-1 alpha Protein has been validated for the following applications: Bioactivity.
target :
CCL3/MIP-1 alpha
category :
Proteins and Enzymes
unit size :
10 ug (also 50 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
theoretical molecular weight :
7.5 kDa
gene symbol :
CCL3
details of functionality :
Measured by its ability to chemoattract 2-day cultured human monocytes. The ED50 for this effect is 2-10 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR5. The ED50 for this effect is 3-10 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
270-LD
accessionNumbers :
P10147
applications :
Bioactivity
source :
E. coli -derived human CCL3/MIP-1 alpha protein Ala27-Ala92
2020 USD :
249
2021 USD :
249 USD
alt names :
C-C motif chemokine 3, MIP1-(a), AI323804, chemokine (C-C motif) ligand 3, G0S19-1, LD78a, LD78alpha, MIP1 alpha, MIP-1 alpha, Mip1a, MIP-1alpha, MIP1-alpha, PAT 464.1, SCYA3, SIS-beta
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information

R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.
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