Recombinant Human IL-1 RI Protein | R&D Systems 269-1R-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-1 RI Protein

catalog :

269-1R-100

quantity :

100 ug

price :

645 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Mahmoudi Azar L, Karaman E, Beyaz B, G xf6 ktan I, Ey xfc po x11f lu A, Kizilel S, et al. Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system. BMC Biotechnol. 2023;23:15 pubmed publisher
Han K, Singh K, Rodman M, Hassanzadeh S, Baumer Y, Huffstutler R, et al. Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. Nutrients. 2021;13: pubmed publisher
Issafras H, Corbin J, Goldfine I, Roell M. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014;348:202-15 pubmed publisher
Narita M, Shimamura M, Imai S, Kubota C, Yajima Y, Takagi T, et al. Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice. Neuroscience. 2008;152:477-86 pubmed publisher
Pfleger C, Schloot N, ter Veld F. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J Immunol Methods. 2008;329:214-8 pubmed
Herrmann Lavoie C, Rao C, Akoum A. Chorionic gonadotropin down-regulates the expression of the decoy inhibitory interleukin 1 receptor type II in human endometrial epithelial cells. Endocrinology. 2007;148:5377-84 pubmed
Grundtman C, Salomonsson S, Dorph C, Bruton J, Andersson U, Lundberg I. Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies. Arthritis Rheum. 2007;56:674-87 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

269-1R

SKU :

269-1R-100

product name :

Recombinant Human IL-1 RI Protein

Description :

The Recombinant Human IL-1 RI Protein from R&D Systems is derived from NS0. The Recombinant Human IL-1 RI Protein has been validated for the following applications: Bioactivity.

target :

IL-1 RI

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

55 kDa, reducing conditions

theoretical molecular weight :

36 kDa

gene symbol :

IL1R1

details of functionality :

Measured by its ability to inhibit IL-1 beta-dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. et al . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 272. Approximately 0.2-1.0 µg/mL of IL-1 RI will inhibit 50% of the biological response due to 30 pg/mL of recombinant human IL-1 beta .

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P14778

applications :

Bioactivity

source :

NS0-derived Recombinant Human IL-1 RI Protein

USD :

645 USD

alt names :

CD121 antigen-like family member A, CD121a, CD121a antigen, IL1R, IL1R1, IL1RI, IL-1RI, IL1RT1, IL-1RT1, IL-1RT-1, Interleukin 1 Receptor 1, interleukin 1 receptor, type I, interleukin receptor 1, interleukin-1 receptor type 1, p80

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage