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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human NT-3 Protein, CF
catalog :
267-N3-005/CF
quantity :
5 ug (also 25 ug)
price :
259 USD
more info or order :
citations: 65
Reference
Martin S, Allan K, Pinkard O, Sweet T, Tesar P, Coller J. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay. Nat Commun. 2022;13:5003 pubmed publisher
Sawamura M, Imamura K, Hikawa R, Enami T, Nagahashi A, Yamakado H, et al. Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation. Sci Rep. 2022;12:12636 pubmed publisher
Eltahir M, Nakamori M, Hattori S, Kimura T, Mochizuki H, Nagano S. Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1. PLoS ONE. 2022;17:e0269683 pubmed publisher
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, et al. Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep. 2022;23:e54041 pubmed publisher
Su xe1 rez Rivero J, Pastor Maldonado C, Romero Gonz xe1 lez A, G xf3 mez Fernandez D, Povea Cabello S, xc1 lvarez C xf3 rdoba M, et al. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases. Front Pharmacol. 2022;13:862085 pubmed publisher
Rousset F, Schmidbauer D, Fink S, Adel Y, Obexer B, Müller M, et al. Phoenix auditory neurons as 3R cell model for high throughput screening of neurogenic compounds. Hear Res. 2022;414:108391 pubmed publisher
Bruzelius A, Kidnapillai S, Drouin Ouellet J, Stoker T, Barker R, Rylander Ottosson D. Reprogramming Human Adult Fibroblasts into GABAergic Interneurons. Cells. 2021;10: pubmed publisher
Segelcke D, Fischer H, Hütte M, Dennerlein S, Benseler F, Brose N, et al. Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice. Cell Rep. 2021;37:110152 pubmed publisher
Göttle P, Schichel K, Reiche L, Werner L, Zink A, Prigione A, et al. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Front Cell Neurosci. 2021;15:777542 pubmed publisher
Chennampally P, Sayed Zahid A, Soundararajan P, Sharp J, Cox G, Collins S, et al. A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin. Sci Rep. 2021;11:18168 pubmed publisher
Jiang H, Niu F, Zheng Y, Xu Y. CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes. Mol Med Rep. 2021;23: pubmed publisher
Merlevede A, Legault E, Drugge V, Barker R, Drouin Ouellet J, Olariu V. A quantitative model of cellular decision making in direct neuronal reprogramming. Sci Rep. 2021;11:1514 pubmed publisher
Kurosaki T, Imamachi N, Proschel C, Mitsutomi S, Nagao R, Akimitsu N, et al. Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay. Nat Cell Biol. 2021;23:40-48 pubmed publisher
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell. 2021;28:257-272.e11 pubmed publisher
Giacomoni J, Bruzelius A, Stamouli C, Rylander Ottosson D. Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons. Cells. 2020;9: pubmed publisher
Nolbrant S, Giacomoni J, Hoban D, Bruzelius A, Birtele M, Chandler Militello D, et al. Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons. Stem Cell Reports. 2020;15:869-882 pubmed publisher
Prautsch K, Schmidt A, Paradiso V, Schaefer D, Guzman R, Kalbermatten D, et al. Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro. Cells. 2020;9: pubmed publisher
Frick C, Fink S, Schmidbauer D, Rousset F, Eickhoff H, Tropitzsch A, et al. Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants. Brain Sci. 2020;10: pubmed publisher
Michel N, Narayanan P, Shomroni O, Schmidt M. Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction. Cell Rep. 2020;32:107912 pubmed publisher
Micali N, Kim S, Diaz Bustamante M, Stein O Brien G, Seo S, Shin J, et al. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Rep. 2020;31:107599 pubmed publisher
Burke E, Chenoweth J, Shin J, Collado Torres L, Kim S, Micali N, et al. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs. Nat Commun. 2020;11:462 pubmed publisher
Nickolls A, Lee M, Espinoza D, Szczot M, Lam R, Wang Q, et al. Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells. Cell Rep. 2020;30:932-946.e7 pubmed publisher
Matjusaitis M, Wagstaff L, Martella A, Baranowski B, Blin C, Gogolok S, et al. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors. Stem Cell Reports. 2019;13:1053-1067 pubmed publisher
Lin C, Yoshida M, Li L, Ikenaka A, Oshima S, Nakagawa K, et al. iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases. JCI Insight. 2019;4: pubmed publisher
Wang Y, Wu H, Fontanet P, Codeluppi S, Akkuratova N, Petitpré C, et al. A cell fitness selection model for neuronal survival during development. Nat Commun. 2019;10:4137 pubmed publisher
Liu Z, Osipovitch M, Benraiss A, Huynh N, Foti R, Bates J, et al. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling. Cell Rep. 2019;27:3832-3843.e6 pubmed publisher
Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, et al. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Zhang J, Wang L, Cao H, Chen N, Yan B, Ao X, et al. Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats. J Cell Mol Med. 2019;23:2595-2609 pubmed publisher
Melamed Z, López Erauskin J, Baughn M, Zhang O, Drenner K, Sun Y, et al. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019;22:180-190 pubmed publisher
Osipovitch M, Asenjo Martinez A, Mariani J, Cornwell A, Dhaliwal S, Zou L, et al. Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation. Cell Stem Cell. 2019;24:107-122.e7 pubmed publisher
Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018;9:2668 pubmed publisher
Gomez D, Byers L, Nilsson M, Diao L, Wang J, Li L, et al. Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non-small cell lung cancer. Oncotarget. 2018;9:14268-14284 pubmed publisher
Göttle P, Manousi A, Kremer D, Reiche L, Hartung H, Küry P. Teriflunomide promotes oligodendroglial differentiation and myelination. J Neuroinflammation. 2018;15:76 pubmed publisher
Avaliani N, Pfisterer U, Heuer A, Parmar M, Kokaia M, Andersson M. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus. Stem Cells Int. 2017;2017:5718608 pubmed publisher
Newman E, Chukkapalli S, Bashllari D, Thomas T, Van Noord R, Lawlor E, et al. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation. Cell Death Dis. 2017;8:3208 pubmed publisher
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher
Zhang M, Jiang M, Kim D, Ahn W, Chung E, Son Y, et al. Comparative Analysis of the Cell Fates of Induced Schwann Cells from Subcutaneous Fat Tissue and Naïve Schwann Cells in the Sciatic Nerve Injury Model. Biomed Res Int. 2017;2017:1252851 pubmed publisher
Drouin Ouellet J, Lau S, Brattås P, Rylander Ottosson D, Pircs K, Grassi D, et al. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017;9:1117-1131 pubmed publisher
Wu W, Wu X, Ji Y, Gao Z. Differentiation of nestin‑negative human hair follicle outer root sheath cells into neurons in vitro. Mol Med Rep. 2017;16:95-100 pubmed publisher
Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, et al. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophr Res. 2017;181:75-82 pubmed publisher
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, et al. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons. Proc Natl Acad Sci U S A. 2017;114:E2486-E2493 pubmed publisher
Goparaju S, Kohda K, Ibata K, Soma A, Nakatake Y, Akiyama T, et al. Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors. Sci Rep. 2017;7:42367 pubmed publisher
Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, et al. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. PLoS ONE. 2017;12:e0171947 pubmed publisher
Huang X, Chen M, Ding Y, Wang Q. Arctigenin protects against neuronal hearing loss by promoting neural stem cell survival and differentiation. Genesis. 2017;55: pubmed publisher
Pfisterer U, Ek F, Lang S, Soneji S, Olsson R, Parmar M. Small molecules increase direct neural conversion of human fibroblasts. Sci Rep. 2016;6:38290 pubmed publisher
Imai F, Ladle D, Leslie J, Duan X, Rizvi T, Ciraolo G, et al. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. J Neurosci. 2016;36:5724-35 pubmed publisher
Bian J, Zheng J, Li S, Luo L, Ding F. Sequential Differentiation of Embryonic Stem Cells into Neural Epithelial-Like Stem Cells and Oligodendrocyte Progenitor Cells. PLoS ONE. 2016;11:e0155227 pubmed publisher
Han K, Woo D, Kim S, Choii G, Jeon S, Won S, et al. Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTP? Synaptic Adhesion and Intracellular Signaling Pathways. J Neurosci. 2016;36:4816-31 pubmed publisher
Li S, Nie E, Yin Y, Benowitz L, Tung S, Vinters H, et al. GDF10 is a signal for axonal sprouting and functional recovery after stroke. Nat Neurosci. 2015;18:1737-45 pubmed publisher
Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, et al. Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs. Stem Cell Reports. 2015;4:561-8 pubmed publisher
Göttle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, et al. Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci. 2015;35:906-19 pubmed publisher
Pereira M, Pfisterer U, Rylander D, Torper O, Lau S, Lundblad M, et al. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep. 2014;4:6330 pubmed publisher
Numasawa Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, et al. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes. Stem Cell Reports. 2014;2:648-61 pubmed publisher
Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, et al. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development. 2014;141:2216-24 pubmed publisher
Zhou Z, Kohda K, Ibata K, Kohyama J, Akamatsu W, Yuzaki M, et al. Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors. Mol Brain. 2014;7:24 pubmed publisher
Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, et al. Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury. Stem Cells Transl Med. 2014;3:334-45 pubmed publisher
Shen W, Zhu L, Lee S, Chung S, Gillies M. Involvement of NT3 and P75(NTR) in photoreceptor degeneration following selective Müller cell ablation. J Neuroinflammation. 2013;10:137 pubmed publisher
Sahenk Z, Galloway G, Clark K, Malik V, Rodino Klapac L, Kaspar B, et al. AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy. Mol Ther. 2014;22:511-521 pubmed publisher
Shim J, Lee T, Shin D. Enrichment and characterization of human dermal stem/progenitor cells by intracellular granularity. Stem Cells Dev. 2013;22:1264-74 pubmed publisher
Erceg S, Lukovic D, Moreno Manzano V, Stojkovic M, Bhattacharya S. Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2012;Chapter 1:Unit 1H.5 pubmed publisher
Demel C, Hoegen T, Giese A, Angele B, Pfister H, Koedel U, et al. Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis. J Neuroinflammation. 2011;8:7 pubmed publisher
Delcroix G, Curtis K, Schiller P, Montero Menei C. EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells. Differentiation. 2010;80:213-27 pubmed publisher
Samah B, Porcheray F, Gras G. Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin Exp Immunol. 2008;151:476-86 pubmed publisher
Ai X, Kitazawa T, Do A, Kusche Gullberg M, Labosky P, Emerson C. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development. 2007;134:3327-38 pubmed
Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
image
image 1 :
R&D Systems 267-N3-005/CF image 1
Recombinant Human NT-3 Protein SDS-PAGE
product information
brand :
R&D Systems
master code :
267-N3/CF
SKU :
267-N3-005/CF
product name :
Recombinant Human NT-3 Protein, CF
description :
The Recombinant Human NT-3 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human NT-3 Protein, CF has been validated for the following applications: Bioactivity.
target :
NT-3
category :
Proteins and Enzymes
unit sizes :
5 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
theoretical molecular weight :
13.7 kDa
gene symbol :
NTF3
details of functionality :
Measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB. The ED50 for this effect is 4-40 ng/mL. The specific activity of recombinant human NT-3 is approximately 2082 U/µg, which is calibrated against Recombinant Human NT-3 Standard (NIBSC code: 98/718).
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P20783
applications :
Bioactivity
source :
Sf 21 (baculovirus)-derived Recombinant Human NT-3 Protein, CF
extended description :
Earn double rewards for reviews
USD :
259 USD
product details :
Earn double rewards for reviews
alt names :
HDNF, MGC129711, Nerve growth factor 2, Neurotrophic factor, neurotrophin 3, neurotrophin-3, NGF2, NGF-2, NT3, NT-3, NTF3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.