Recombinant Human Biglycan Protein, CF | R&D Systems 2667-CM-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Biglycan Protein, CF

catalog :

2667-CM-050

quantity :

50 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Gerhardy S, Ultsch M, Tang W, Green E, Holden J, Li W, et al. Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun. 2022;13:5222 pubmed publisher
Hoermann H, Krueger I, Maurus N, Reusswig F, Sun Y, Kohlmorgen C, et al. The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner. Int J Mol Sci. 2021;22: pubmed publisher
Bisson D, Sheng K, Kocabas S, Krock E, Teles A, Saran N, et al. Toll-like receptor involvement in adolescent scoliotic facet joint degeneration. J Cell Mol Med. 2020;24:11355-11365 pubmed publisher
Asega A, Menezes M, Trevisan Silva D, Cajado Carvalho D, Bertholim L, Oliveira A, et al. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Sci Rep. 2020;10:12912 pubmed publisher
Ferraro D, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, et al. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells. BMC Cancer. 2019;19:312 pubmed publisher
Jongwattanapisan P, Terajima M, Miguez P, Querido W, Nagaoka H, Sumida N, et al. Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function. Sci Rep. 2018;8:7022 pubmed publisher
Mayer C, Adam M, Glashauser L, Dietrich K, Schwarzer J, Kohn F, et al. Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells. Sci Rep. 2016;6:37128 pubmed publisher
Rzeniewicz K, Newe A, Rey Gallardo A, Davies J, Holt M, Patel A, et al. L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc Natl Acad Sci U S A. 2015;112:E1461-70 pubmed publisher
Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagälv A, et al. Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem. 2014;289:237-50 pubmed publisher
Kitaya K, Yasuo T. Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium. J Leukoc Biol. 2009;85:391-400 pubmed publisher

product information

brand :

R&D Systems

master code :

2667-CM

SKU :

2667-CM-050

product name :

Recombinant Human Biglycan Protein, CF

description :

The Recombinant Human Biglycan Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Biglycan Protein, CF has been validated for the following applications: Bioactivity.

target :

Biglycan

category :

Proteins and Enzymes

unit sizes :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

40-45 kDa, reducing conditions

theoretical molecular weight :

38 kDa

gene symbol :

BGN

details of functionality :

Measured by its ability to inhibit the cell growth of mouse 3T3-L1 mouse embryonic fibroblast adipose-like cells. Ward, M. and Ajuwon, K.M. (2011) Cell Proliferation 44 :343. The ED50 for this effect is 1.5-6 µg/mL. Measured by its ability to increase the binding of BMP-4 to Chordin. Moreno, M. et al . (2005) EMBO J. 24 :1397. 2-8 µg/mL of Recombinant Human Biglycan will have a 50% maximum increase in the binding of recombinant human BMP-4 (0.1 µg/mL) to recombinant mouse Chordin (1 µg/mL).

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P21810

applications :

Bioactivity

source :

NS0-derived Recombinant Human Biglycan Protein, CF

USD :

394 USD

alt names :

BGN, biglycan, Bone/cartilage proteoglycan I, bone/cartilage proteoglycan-I, dermatan sulphate proteoglycan I, DSPG1, PGI, PG-S1, SLRR1A, SLRR1Abiglycan proteoglycan, small leucine-rich protein 1A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage