Recombinant Human PlGF Protein | R&D Systems 264-PGB-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PlGF Protein

catalog :

264-PGB-010

quantity :

10 ug (also 50 ug)

price :

355 USD

more info or order :

R&D Systems product webpage

citations: 31

Reference
Moon S, Kim H, Kim J, Kim J, Choi J, Won S, et al. An examination of the mechanisms driving the therapeutic effects of an AAV expressing a soluble variant of VEGF receptor-1. PLoS ONE. 2024;19:e0305466 pubmed publisher
Tarallo V, Magliacane Trotta S, Panico S, D Orsi L, Mercadante G, Cicatiello V, et al. PlGF and VEGF-A/PlGF Heterodimer are Crucial for Recruitment and Activation of Immune Cells During Choroid Neovascularization. Invest Ophthalmol Vis Sci. 2024;65:12 pubmed publisher
Matsuyama T, Tomimatsu T, Mimura K, Yagi K, Kawanishi Y, Kakigano A, et al. Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia. J Reprod Immunol. 2021;145:103322 pubmed publisher
Nagano H, Tomida C, Yamagishi N, Teshima Kondo S. VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Jauhiainen S, Laakkonen J, Ketola K, Toivanen P, Nieminen T, Ninchoji T, et al. Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function. Front Physiol. 2019;10:224 pubmed publisher
Zhang Y, Cao C, Xin J, Lv P, Chen D, Li S, et al. Treatment with placental growth factor attenuates myocardial ischemia/reperfusion injury. PLoS ONE. 2018;13:e0202772 pubmed publisher
Gu J, Yuan S, Sim D, Abe K, Liu P, Rosenbruch M, et al. Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease. Exp Hematol. 2018;60:73-82.e3 pubmed publisher
Li X, Yao Q, Liu H, Jin Q, Xu B, Zhang S, et al. Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. J Cell Mol Med. 2017;21:2370-2385 pubmed publisher
Wu D, Lai T, Yuan Y, Chen M, Xia J, Li W, et al. Elevated expression of placental growth factor is associated with airway-wall vascular remodelling and thickening in smokers with asthma. Sci Rep. 2017;7:43017 pubmed publisher
Hookham M, Ali I, O Neill C, Hackett E, Lambe M, Schmidt T, et al. Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor. Stem Cell Res Ther. 2016;7:173 pubmed
Li C, Gonsalves C, Eiymo Mwa Mpollo M, Malik P, Tahara S, Kalra V. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. Mol Cell Biol. 2015;35:514-28 pubmed publisher
Hou H, Cheng S, Chung K, Kuo M, Yeh C, Chang B, et al. Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis. Autophagy. 2014;10:1509-21 pubmed publisher
Park S, Kim K, Kim W, Cho C. Interaction of mesenchymal stem cells with fibroblast-like synoviocytes via cadherin-11 promotes angiogenesis by enhanced secretion of placental growth factor. J Immunol. 2014;192:3003-10 pubmed publisher
Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I. Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin. PLoS ONE. 2013;8:e56754 pubmed publisher
Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, et al. Endorepellin, the angiostatic module of perlecan, interacts with both the ?2?1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism. J Biol Chem. 2011;286:25947-62 pubmed publisher
Brave S, Eberlein C, Shibuya M, Wedge S, Barry S. Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. Angiogenesis. 2010;13:337-47 pubmed publisher
Patel N, Sundaram N, Yang M, Madigan C, Kalra V, Malik P. Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem. 2010;285:16713-22 pubmed publisher
Matsunaga Y, Yamazaki Y, Suzuki H, Morita T. VEGF-A and VEGF-F evoke distinct changes in vascular ultrastructure. Biochem Biophys Res Commun. 2009;379:872-5 pubmed publisher
Ponticelli S, Marasco D, Tarallo V, Albuquerque R, Mitola S, Takeda A, et al. Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1. J Biol Chem. 2008;283:34250-9 pubmed publisher
Zhang Z, Ramirez N, Yankeelov T, Li Z, Ford L, Qi Y, et al. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Blood. 2008;111:1980-8 pubmed
Lin Y, Liang Y, Chiang B. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J Leukoc Biol. 2007;82:1473-80 pubmed
Mohamedali K, Poblenz A, Sikes C, Navone N, Thorpe P, Darnay B, et al. Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel. Cancer Res. 2006;66:10919-28 pubmed
Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal P, Pesce M, et al. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am J Pathol. 2006;169:1167-82 pubmed
Moreno M, Ball M, Andrade M, McDermid A, Stanimirovic D. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia. 2006;53:845-57 pubmed
Nozaki M, Sakurai E, Raisler B, Baffi J, Witta J, Ogura Y, et al. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest. 2006;116:422-9 pubmed
Niida S, Kondo T, Hiratsuka S, Hayashi S, Amizuka N, Noda T, et al. VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice. Proc Natl Acad Sci U S A. 2005;102:14016-21 pubmed
Sun J, Phung T, Shiojima I, Felske T, Upalakalin J, Feng D, et al. Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A. 2005;102:128-33 pubmed
Dikov M, Ohm J, Ray N, Tchekneva E, Burlison J, Moghanaki D, et al. Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J Immunol. 2005;174:215-22 pubmed
Tamarat R, Silvestre J, Le Ricousse Roussanne S, Barateau V, Lecomte Raclet L, Clergue M, et al. Impairment in ischemia-induced neovascularization in diabetes: bone marrow mononuclear cell dysfunction and therapeutic potential of placenta growth factor treatment. Am J Pathol. 2004;164:457-66 pubmed
Maynard S, Min J, Merchan J, Lim K, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649-58 pubmed
Oura H, Bertoncini J, Velasco P, Brown L, Carmeliet P, Detmar M. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood. 2003;101:560-7 pubmed

product information

master code :

264-PGB

SKU :

264-PGB-010

product name :

Recombinant Human PlGF Protein

unit size :

10 ug (also 50 ug)

description :

The Recombinant Human PlGF Protein from R&D Systems is derived from E. coli. The Recombinant Human PlGF Protein has been validated for the following applications: Bioactivity.

target :

PlGF

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

12-15 kDa, reducing conditions

theoretical molecular weight :

15 kDa

gene symbol :

PGF

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human VEGF R1/Flt-1 Fc Chimera (Catalog # 3516-FL ) is immobilized at 0.5 ╡g/mL, 100 ╡L/well, the concentration of Recombinant Human PlGF that produces 50% of the optimal binding response is approximately 0.75-4.5 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_001193941.1

applications :

Bioactivity

source long :

E. coli -derived human PlGF protein Ala21-Arg149

source short :

E. coli

USD :

355 USD

alt names :

D12S1900, PGF, PGFL, placenta growth factor, placental growth factor, placental growth factor, vascular endothelial growth factor-related protein, PlGF, PlGF-2, PLGFplacental growth factor-like, SHGC-10760

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage