Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF | R&D Systems 2639-AO product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF

catalog :

2639-AO

quantity :

10 ug

price :

429 USD

citations: 6

Reference
Leeming D, Willumsen N, Sand J, Holm Nielsen S, Dasgupta B, Brodmerkel C, et al. A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis. Biochem Biophys Rep. 2019;17:38-43 pubmed publisher
Schilter H, Findlay A, Perryman L, Yow T, Moses J, Zahoor A, et al. The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis. J Cell Mol Med. 2019;23:1759-1770 pubmed publisher
Wei Y, Kim T, Peng D, Duan D, Gibbons D, Yamauchi M, et al. Fibroblast-specific inhibition of TGF-?1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127:3675-3688 pubmed publisher
Aumiller V, Strobel B, Romeike M, Schuler M, Stierstorfer B, Kreuz S. Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis. Sci Rep. 2017;7:149 pubmed publisher
Schilter H, Collison A, Russo R, Foot J, Yow T, Vieira A, et al. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015;16:42 pubmed publisher
Vonk W, de Bie P, Wichers C, van den Berghe P, van der Plaats R, Berger R, et al. The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. Cell Mol Life Sci. 2012;69:149-63 pubmed publisher

product information

brand :

R&D Systems

master code :

2639-AO

SKU :

2639-AO-010

product name :

Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF

description :

The Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Lysyl Oxidase Homolog 2/LOXL2

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

85 kDa

gene symbol :

LOXL2

details of functionality :

Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is 2 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

2639-AO

accessionNumbers :

AAH00594

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human Lysyl Oxidase Homolog 2/LOXL2 protein Met1-Gln774, with a C-terminal 10-His tag

2020 USD :

429

2021 USD :

429 USD

alt names :

EC 1.4.3, EC 1.4.3.-, LOL2, LOR2, LOXL2, lysyl oxidase homolog 2, lysyl oxidase related 2, lysyl oxidase-like 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14, WS9-14

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.