product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF
catalog :
2639-AO-010
quantity :
10 ug
price :
540 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Chaudhari N, Findlay A, Stevenson A, Clemons T, Yao Y, Joshi A, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022;13:5555 pubmed publisher
Zhang C, Zhu M, Wang H, Wen J, Huang Z, Chen S, et al. LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling. Sci Rep. 2021;11:17020 pubmed publisher
Vallet S, Berthollier C, Salza R, Muller L, Ricard Blum S. The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins. Cancers (Basel). 2020;13: pubmed publisher
Leeming D, Willumsen N, Sand J, Holm Nielsen S, Dasgupta B, Brodmerkel C, et al. A serological marker of the N-terminal neoepitope generated during LOXL2 maturation is elevated in patients with cancer or idiopathic pulmonary fibrosis. Biochem Biophys Rep. 2019;17:38-43 pubmed publisher
Schilter H, Findlay A, Perryman L, Yow T, Moses J, Zahoor A, et al. The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis. J Cell Mol Med. 2019;23:1759-1770 pubmed publisher
Wei Y, Kim T, Peng D, Duan D, Gibbons D, Yamauchi M, et al. Fibroblast-specific inhibition of TGF-?1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127:3675-3688 pubmed publisher
Aumiller V, Strobel B, Romeike M, Schuler M, Stierstorfer B, Kreuz S. Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis. Sci Rep. 2017;7:149 pubmed publisher
Schilter H, Collison A, Russo R, Foot J, Yow T, Vieira A, et al. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration. Respir Res. 2015;16:42 pubmed publisher
Vonk W, de Bie P, Wichers C, van den Berghe P, van der Plaats R, Berger R, et al. The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. Cell Mol Life Sci. 2012;69:149-63 pubmed publisher
product information
master code :
2639-AO
SKU :
2639-AO-010
product name :
Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF
unit size :
10 ug
description :
The Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Lysyl Oxidase Homolog 2 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Lysyl Oxidase Homolog 2/LOXL2
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
100-110 kDa, reducing conditions
theoretical molecular weight :
85 kDa
gene symbol :
LOXL2
details of functionality :
Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is 2 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Lysyl Oxidase Homolog 2 Protein SDS-PAGE
accessionNumbers :
AAH00594
applications :
Enzyme Activity
source long :
Mouse myeloma cell line, NS0-derived human Lysyl Oxidase Homolog 2/LOXL2 protein Met1-Gln774, with a C-terminal 10-His tag
source short :
NS0
USD :
540 USD
alt names :
EC 1.4.3, EC 1.4.3.-, LOL2, LOR2, LOXL2, lysyl oxidase homolog 2, lysyl oxidase related 2, lysyl oxidase-like 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14, WS9-14
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.