product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse FGF-23 Protein, CF
catalog :
2629-FG-025/CF
quantity :
25 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 25
Reference
Meyer M, Benkusky N, Lee S, Yoon S, MANNSTADT M, Wein M, et al. Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules. J Biol Chem. 2022;298:102559 pubmed publisher
Czaya B, Heitman K, Campos I, Yanucil C, Kentrup D, Westbrook D, et al. Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling. elife. 2022;11: pubmed publisher
Navarro Garc xed a J, Salguero Bodes R, Gonz xe1 lez Lafuente L, Mart xed n Nunes L, Rodr xed guez S xe1 nchez E, Bada Bosch T, et al. The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23. BMC Med. 2022;20:14 pubmed publisher
Lee T, Chung C, Lee T, Lin Y, Kao Y, Chen Y. Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling. Int J Mol Sci. 2021;23: pubmed publisher
Chen W. Soluble Alpha-Klotho Alleviates Cardiac Fibrosis without Altering Cardiomyocytes Renewal. Int J Mol Sci. 2020;21: pubmed publisher
Westphal S, Gantert T, Kless C, Hüttinger K, Klingenspor M, Fromme T. Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. Sci Rep. 2019;9:8470 pubmed publisher
Meyer M, Benkusky N, Kaufmann M, Lee S, Redfield R, Jones G, et al. Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse. J Biol Chem. 2019;294:9518-9535 pubmed publisher
Zhu L, Stein L, Kim D, Ho K, Yu G, Zhan L, et al. Klotho controls the brain-immune system interface in the choroid plexus. Proc Natl Acad Sci U S A. 2018;115:E11388-E11396 pubmed publisher
Quarto N, Shailendra S, Meyer N, Menon S, Renda A, Longaker M. Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23. Front Physiol. 2018;9:1426 pubmed publisher
Kägi L, Bettoni C, Pastor Arroyo E, Schnitzbauer U, Hernando N, Wagner C. Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3. PLoS ONE. 2018;13:e0195427 pubmed publisher
Yashiro M, Ohya M, Mima T, Ueda Y, Nakashima Y, Kawakami K, et al. FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells. Int J Nephrol Renovasc Dis. 2018;11:125-136 pubmed publisher
Agoro R, Montagna A, Goetz R, Aligbe O, Singh G, Coe L, et al. Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia. FASEB J. 2018;32:3752-3764 pubmed publisher
Si W, Zhang Y, Chen K, Hu D, Qian Z, Gong S, et al. Fibroblast growth factor type 1 receptor stimulation of T-type Ca2+ channels in sensory neurons requires the phosphatidylinositol 3-kinase and protein kinase A pathways, independently of Akt. Cell Signal. 2018;45:93-101 pubmed publisher
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, et al. Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 2017;127:3496-3509 pubmed publisher
Smith E, Tan S, Holt S, Hewitson T. FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts. Sci Rep. 2017;7:3345 pubmed publisher
Grabner A, Schramm K, Silswal N, Hendrix M, Yanucil C, Czaya B, et al. FGF23/FGFR4-mediated left ventricular hypertrophy is reversible. Sci Rep. 2017;7:1993 pubmed publisher
Guibert M, Gasser A, Kempf H, Bianchi A. Fibroblast-growth factor 23 promotes terminal differentiation of ATDC5 cells. PLoS ONE. 2017;12:e0174969 pubmed publisher
Kawakami K, Takeshita A, Furushima K, Miyajima M, Hatamura I, Kuro O M, et al. Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 2017;7:40534 pubmed publisher
Lindberg I, Pang H, Stains J, Clark D, Yang A, Bonewald L, et al. FGF23 is endogenously phosphorylated in bone cells. J Bone Miner Res. 2015;30:449-54 pubmed publisher
Ohata Y, Yamazaki M, Kawai M, Tsugawa N, Tachikawa K, Koinuma T, et al. Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014;29:1627-38 pubmed publisher
Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, et al. FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J. 2014;33:229-46 pubmed publisher
Touchberry C, Green T, Tchikrizov V, Mannix J, Mao T, Carney B, et al. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. Am J Physiol Endocrinol Metab. 2013;304:E863-73 pubmed publisher
Lau W, Leaf E, Hu M, Takeno M, Kuro O M, Moe O, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int. 2012;82:1261-70 pubmed publisher
Faul C, Amaral A, Oskouei B, Hu M, Sloan A, Isakova T, et al. FGF23 induces left ventricular hypertrophy. J Clin Invest. 2011;121:4393-408 pubmed publisher
Galitzer H, Ben Dov I, Silver J, Naveh Many T. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int. 2010;77:211-8 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
2629-FG/CF
SKU :
2629-FG-025/CF
product name :
Recombinant Mouse FGF-23 Protein, CF
Description :
The Recombinant Mouse FGF-23 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse FGF-23 Protein, CF has been validated for the following applications: Bioactivity.
target :
FGF-23
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4, EDTA and DTT.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
30-32 kDa, reducing conditions
theoretical molecular weight :
26.1 kDa
gene symbol :
Fgf23
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is 0.2-1.2 µg/mL in the presence of Recombinant Mouse Klotho (Catalog # 1819-KL ) and heparin.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9EPC2
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse FGF-23 Protein
USD :
423 USD
alt names :
ADHR, FGF23, FGF-23, fibroblast growth factor 23, HPDR2, HYPF, Phosphatonin, PHPTC, tumor-derived hypophosphatemia inducing factor, Tumor-derived hypophosphatemia-inducing factor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.