This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Kallikrein 7 Protein, CF
catalog :
2624-SE
quantity :
10 ug
price :
339 USD
citations: 9
Reference
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, et al. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med. 2018;10: pubmed publisher
Fortelny N, Butler G, Overall C, Pavlidis P. Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions. Mol Cell Proteomics. 2017;16:1038-1051 pubmed publisher
Yamamoto Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, et al. Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation. J Biol Chem. 2014;289:20026-38 pubmed publisher
Fortugno P, Bresciani A, Paolini C, Pazzagli C, El Hachem M, D Alessio M, et al. Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: implications for skin homeostasis. J Invest Dermatol. 2011;131:2223-32 pubmed publisher
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schroder J, et al. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides. 2011;32:1187-92 pubmed publisher
Meyer Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, et al. Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem. 2010;285:32174-81 pubmed publisher
Sales K, Masedunskas A, Bey A, Rasmussen A, Weigert R, List K, et al. Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet. 2010;42:676-83 pubmed publisher
Morizane S, Yamasaki K, Kabigting F, Gallo R. Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid. J Invest Dermatol. 2010;130:1297-306 pubmed publisher
Sexton D, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, et al. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009;422:383-92 pubmed publisher
product information
brand :
R&D Systems
master code :
2624-SE
SKU :
2624-SE-010
product name :
Recombinant Human Kallikrein 7 Protein, CF
description :
The Recombinant Human Kallikrein 7 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Kallikrein 7 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Kallikrein 7
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in HEPES and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
29 kDa and 32 kDa, reducing conditions
theoretical molecular weight :
26 kDa
gene symbol :
KLK7
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002 ). The specific activity is 150 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
2624-SE
accessionNumbers :
P49862
applications :
Enzyme Activity
source :
Mouse myeloma cell line, NS0-derived human Kallikrein 7 protein Glu23-His252, with a C-terminal 10-His tag
2020 USD :
339
2021 USD :
339 USD
alt names :
EC 3.4.21, EC 3.4.21.117, hK7, hSCCE, kallikrein 7 (chymotryptic, stratum corneum), kallikrein-related peptidase 7, KLK7, protease, serine, 6, PRSS6, SCCEkallikrein-7, Serine protease 6, signal protein, Stratum corneum chymotryptic enzyme
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.