Recombinant Human TLR2 Protein, CF | R&D Systems 2616-TR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TLR2 Protein, CF

catalog :

2616-TR-050

quantity :

50 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 13

Reference
Xie X, Lv H, Liu C, Su X, Yu Z, Song S, et al. HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis. BMC Med. 2021;19:247 pubmed publisher
He X, Howard B, Liu Y, Neumann A, Li L, Menon N, et al. LYSMD3: A mammalian pattern recognition receptor for chitin. Cell Rep. 2021;36:109392 pubmed publisher
Wu S, Teo B, Wee S, Chen J, Lu J. The GAR/RGG motif defines a family of nuclear alarmins. Cell Death Dis. 2021;12:477 pubmed publisher
Zheng M, Ambesi A, McKeown Longo P. Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin. Cells. 2020;9: pubmed publisher
Raby A, González Mateo G, Williams A, Topley N, Fraser D, López Cabrera M, et al. Targeting Toll-like receptors with soluble Toll-like receptor 2 prevents peritoneal dialysis solution-induced fibrosis. Kidney Int. 2018;94:346-362 pubmed publisher
Qadri M, Almadani S, Jay G, Elsaid K. Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines. J Immunol. 2018;200:758-767 pubmed publisher
Durai P, Shin H, Achek A, Kwon H, Govindaraj R, Panneerselvam S, et al. Toll-like receptor 2 antagonists identified through virtual screening and experimental validation. FEBS J. 2017;284:2264-2283 pubmed publisher
Lheure C, Grange P, Ollagnier G, Morand P, Desire N, Sayon S, et al. TLR-2 Recognizes Propionibacterium acnes CAMP Factor 1 from Highly Inflammatory Strains. PLoS ONE. 2016;11:e0167237 pubmed publisher
Raby A, Colmont C, Kift Morgan A, Köhl J, Eberl M, Fraser D, et al. Toll-Like Receptors 2 and 4 Are Potential Therapeutic Targets in Peritoneal Dialysis-Associated Fibrosis. J Am Soc Nephrol. 2017;28:461-478 pubmed publisher
Langjahr P, DÃaz JimÃ©nez D, De la Fuente M, Rubio E, Golenbock D, Bronfman F, et al. Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production. PLoS ONE. 2014;9:e104624 pubmed publisher
Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS ONE. 2011;6:e23132 pubmed publisher
Chambers M, Whelan A, Spallek R, Singh M, Coddeville B, Guerardel Y, et al. Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9. Biochem Biophys Res Commun. 2010;400:403-8 pubmed publisher
Zunt S, Burton L, Goldblatt L, Dobbins E, Srinivasan M. Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells. Clin Exp Immunol. 2009;156:285-93 pubmed publisher

product information

brand :

R&D Systems

master code :

2616-TR

SKU :

2616-TR-050

product name :

Recombinant Human TLR2 Protein, CF

description :

The Recombinant Human TLR2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TLR2 Protein, CF has been validated for the following applications: Binding Activity.

target :

TLR2

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS, NaCl and PEG 3350 with Trehalose.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

75-80 kDa, reducing conditions

theoretical molecular weight :

65.7 kDa

gene symbol :

TLR2

details of functionality :

Measured by its ability to bind biotinylated Pam3CysSerLys4 (PAM3CSK4) (2 µg/mL). The 50% maximum binding is achieved at 0.1-0.5 µg/mL of Recombinant Human TLR2. . Results can vary with different preparations of biotinylated PAM3CSK4. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_003255

applications :

Binding Activity

source :

NS0-derived Recombinant Human TLR2 Protein, CF

USD :

394 USD

alt names :

CD282, CD282 antigen, TIL4CD282, toll/interleukin 1 receptor-like 4, Toll/interleukin-1 receptor-like protein 4, toll-like receptor 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage