Recombinant Human Betacellulin Protein | R&D Systems 261-CE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Betacellulin Protein

catalog :

261-CE-010

quantity :

10 ug (also 50 ug, 250 ug, 1000 ug)

price :

323 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Nair A, Traurig M, Sutherland J, Muller Y, Grellinger E, Saporito L, et al. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. Cells. 2022;11: pubmed publisher
Hogrebe N, Augsornworawat P, Maxwell K, Velazco Cruz L, Millman J. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol. 2020;38:460-470 pubmed publisher
Wang Y, Lifshitz L, Gellatly K, Vinton C, Busman Sahay K, McCauley S, et al. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020;21:274-286 pubmed publisher
Zhao J, Klausen C, Yi Y, Cheng J, Chang H, Leung P. Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling. Cell Signal. 2020;65:109439 pubmed publisher
Zou C, Lu Y, Teng X, Wang S, Sun X, Huang F, et al. MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys. Sci Rep. 2017;7:2505 pubmed publisher
Parry T, Ganguly A, Troy E, Luis Guerrero J, Iaci J, Srinivas M, et al. Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction. Eur J Pharmacol. 2017;796:76-89 pubmed publisher
Iaci J, Ganguly A, Finklestein S, Parry T, Ren J, Saha S, et al. Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke. Neuropharmacology. 2010;59:640-9 pubmed publisher
Shin S, Li N, Kobayashi N, Yoon J, Jun H. Remission of diabetes by beta-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin. Mol Ther. 2008;16:854-61 pubmed publisher
Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression. J Endocrinol. 2006;191:65-81 pubmed
Sanderson M, Abbott C, Tada H, Seno M, Dempsey P, Dunbar A. Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding. J Cell Biochem. 2006;99:609-23 pubmed

product information

brand :

R&D Systems

master code :

261-CE

SKU :

261-CE-010

product name :

Recombinant Human Betacellulin Protein

description :

The Recombinant Human Betacellulin Protein from R&D Systems is derived from E. coli. The Recombinant Human Betacellulin Protein has been validated for the following applications: Bioactivity.

target :

Betacellulin/BTC

category :

Proteins and Enzymes

sizes available :

10 ug (also 50 ug, 250 ug, 1000 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

15 kDa, reducing conditions

theoretical molecular weight :

9 kDa

gene symbol :

BTC

details of functionality :

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al . (1991) Proc. Natl. Acad. Sci. USA 88 :415. The ED50 for this effect is 0.15-0.6 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P35070

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Betacellulin Protein

USD :

323

USD 2023 :

323 USD

alt names :

betacellulin, BTC, probetacellulin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage