product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Betacellulin Protein, CF
catalog :
261-CE-010/CF
quantity :
10 ug (also 50 ug, 250 ug, 1000 ug)
price :
323 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Nair A, Traurig M, Sutherland J, Muller Y, Grellinger E, Saporito L, et al. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. Cells. 2022;11: pubmed publisher
Hogrebe N, Augsornworawat P, Maxwell K, Velazco Cruz L, Millman J. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol. 2020;38:460-470 pubmed publisher
Wang Y, Lifshitz L, Gellatly K, Vinton C, Busman Sahay K, McCauley S, et al. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020;21:274-286 pubmed publisher
Zhao J, Klausen C, Yi Y, Cheng J, Chang H, Leung P. Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling. Cell Signal. 2020;65:109439 pubmed publisher
Zou C, Lu Y, Teng X, Wang S, Sun X, Huang F, et al. MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys. Sci Rep. 2017;7:2505 pubmed publisher
Parry T, Ganguly A, Troy E, Luis Guerrero J, Iaci J, Srinivas M, et al. Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction. Eur J Pharmacol. 2017;796:76-89 pubmed publisher
Iaci J, Ganguly A, Finklestein S, Parry T, Ren J, Saha S, et al. Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke. Neuropharmacology. 2010;59:640-9 pubmed publisher
Shin S, Li N, Kobayashi N, Yoon J, Jun H. Remission of diabetes by beta-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin. Mol Ther. 2008;16:854-61 pubmed publisher
Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression. J Endocrinol. 2006;191:65-81 pubmed
Sanderson M, Abbott C, Tada H, Seno M, Dempsey P, Dunbar A. Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding. J Cell Biochem. 2006;99:609-23 pubmed
product information
brand :
R&D Systems
master code :
261-CE/CF
SKU :
261-CE-010/CF
product name :
Recombinant Human Betacellulin Protein, CF
description :
The Recombinant Human Betacellulin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Betacellulin Protein, CF has been validated for the following applications: Bioactivity.
target :
Betacellulin/BTC
category :
Proteins and Enzymes
sizes available :
10 ug (also 50 ug, 250 ug, 1000 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
15 kDa, reducing conditions
theoretical molecular weight :
9 kDa
gene symbol :
BTC
details of functionality :
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al . (1991) Proc. Natl. Acad. Sci. USA 88 :415. The ED50 for this effect is 0.15-0.6 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P35070
applications :
Bioactivity
source :
E. coli-derived Recombinant Human Betacellulin Protein, CF
USD :
323
USD 2023 :
323 USD
alt names :
betacellulin, BTC, probetacellulin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.