This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FGF-23 Protein
catalog :
2604-FG
quantity :
25 ug
price :
289 USD
citations: 12
Reference
Böckmann I, Lischka J, Richter B, Deppe J, Rahn A, Fischer D, et al. FGF23-Mediated Activation of Local RAAS Promotes Cardiac Hypertrophy and Fibrosis. Int J Mol Sci. 2019;20: pubmed publisher
Rodrat M, Wongdee K, Panupinthu N, Thongbunchoo J, Teerapornpuntakit J, Krishnamra N, et al. Prolonged exposure to 1,25(OH)2D3 and high ionized calcium induces FGF-23 production in intestinal epithelium-like Caco-2 monolayer: A local negative feedback for preventing excessive calcium transport. Arch Biochem Biophys. 2018;640:10-16 pubmed publisher
Yang K, Peretz Soroka H, Wu J, Zhu L, Cui X, Zhang M, et al. Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices. Sci Rep. 2017;7:3100 pubmed publisher
Chung C, Chang Y, Ding Y, Lim K, Liu Q, Zhu L, et al. ?-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells. PLoS ONE. 2017;12:e0176817 pubmed publisher
Sneddon W, Ruiz G, Gallo L, Xiao K, Zhang Q, Rbaibi Y, et al. Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport. J Biol Chem. 2016;291:18632-42 pubmed publisher
van der Meijden K, van Essen H, Bloemers F, Schulten E, Lips P, Bravenboer N. Regulation of CYP27B1 mRNA Expression in Primary Human Osteoblasts. Calcif Tissue Int. 2016;99:164-73 pubmed publisher
Six I, Okazaki H, Gross P, Cagnard J, Boudot C, Maizel J, et al. Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endothelium. PLoS ONE. 2014;9:e93423 pubmed publisher
Coe L, Madathil S, Casu C, Lanske B, Rivella S, Sitara D. FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis. J Biol Chem. 2014;289:9795-810 pubmed publisher
Kharitonenkov A, Beals J, Micanovic R, Strifler B, Rathnachalam R, Wroblewski V, et al. Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319. PLoS ONE. 2013;8:e58575 pubmed publisher
Wu A, Feng B, Chen M, Kolumam G, Zavala Solorio J, Wyatt S, et al. Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. PLoS ONE. 2013;8:e57322 pubmed publisher
Smith R, O Bryan L, Farrow E, Summers L, Clinkenbeard E, Roberts J, et al. Circulating ?Klotho influences phosphate handling by controlling FGF23 production. J Clin Invest. 2012;122:4710-5 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
product information
brand :
R&D Systems
master code :
2604-FG
SKU :
2604-FG-025
product name :
Recombinant Human FGF-23 Protein
description :
The Recombinant Human FGF-23 Protein from R&D Systems is derived from NS0. The Recombinant Human FGF-23 Protein has been validated for the following applications: Bioactivity.
target :
FGF-23
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4, EDTA and DTT with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
29-34 kDa, reducing conditions
theoretical molecular weight :
26.1 kDa
gene symbol :
FGF23
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is 0.1-0.4 µg/mL in the presence of Recombinant Mouse Klotho (Catalog # 1819-KL ) and heparin.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
2604-FG
accessionNumbers :
Q9GZV9
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human FGF-23 protein Tyr25-Ile251 (Arg179Gln), with a C-terminal 6-His tag
2020 USD :
289
2021 USD :
289 USD
alt names :
ADHR, FGF23, FGF-23, fibroblast growth factor 23, HPDR2, HYPF, Phosphatonin, PHPTC, tumor-derived hypophosphatemia inducing factor, Tumor-derived hypophosphatemia-inducing factor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.