Recombinant Human HB-EGF Protein | R&D Systems 259-HE product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human HB-EGF Protein

catalog :

259-HE

quantity :

50 ug (also 250 ug)

price :

179 USD

citations: 50

Reference
Yu H, Duan C, Yang Z, Wang Y, Yue Z, Guo B. HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage. Oxid Med Cell Longev. 2019;2019:6170936 pubmed publisher
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Huynh M, Ouidja M, Chantepie S, Carpentier G, Maïza A, Zhang G, et al. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PLoS ONE. 2019;14:e0209573 pubmed publisher
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Lai T, Li Y, Chen M, Pan G, Wen X, Mai Z, et al. Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition. Lab Invest. 2018;98:1159-1169 pubmed publisher
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Tanaka T, Zhou Y, Ozawa T, Okizono R, Banba A, Yamamura T, et al. Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation. J Biol Chem. 2018;293:2288-2301 pubmed publisher
Kim S, Yang L, Kim S, Lee R, Graham M, Berliner J, et al. Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development. PLoS ONE. 2017;12:e0182566 pubmed publisher
Venkataraman T, Coleman C, Frieman M. Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. J Virol. 2017;91: pubmed publisher
Kizawa K, Fujimori T, Kawai T. Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles. Biol Pharm Bull. 2017;40:516-523 pubmed publisher
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Yasui T, Masaki T, Arita Y, Ishibashi T, Inagaki T, Okazawa M, et al. Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes. PLoS ONE. 2016;11:e0166710 pubmed publisher
Gao J, Ulekleiv C, Halstensen T. Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression. J Exp Clin Cancer Res. 2016;35:151 pubmed
Shim J, Sandlund J, Hameed M, Blazer Yost B, Zhou F, Klagsbrun M, et al. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016;6:26794 pubmed publisher
Veltmann M, Hollborn M, Reichenbach A, Wiedemann P, Kohen L, Bringmann A. Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0147312 pubmed publisher
Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015;526:583-6 pubmed publisher
Li D, Wang A, Liu X, Meisgen F, GrÃ¼nler J, Botusan I, et al. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. J Clin Invest. 2015;125:3008-26 pubmed publisher
Geiger Maor A, Guedj A, Even Ram S, Smith Y, Galun E, Rachmilewitz J. Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism. Cancer Res. 2015;75:2663-73 pubmed publisher
Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, et al. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol. 2015;135:1771-1780 pubmed publisher
Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, et al. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014;10:e1004451 pubmed publisher
Peterson J, Phelps E, Doll M, Schaal S, Ceresa B. The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis. Invest Ophthalmol Vis Sci. 2014;55:2870-80 pubmed publisher
Cole C, Rushton G, Jayson G, Avizienyte E. Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling. J Biol Chem. 2014;289:10488-501 pubmed publisher
Shi C, Washington M, Chaturvedi R, Drosos Y, Revetta F, Weaver C, et al. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest. 2014;94:409-21 pubmed publisher
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Fortian A, Sorkin A. Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis. J Cell Sci. 2014;127:432-44 pubmed publisher
Pawar S, Starosvetsky E, Orvis G, Behringer R, Bagchi I, Bagchi M. STAT3 regulates uterine epithelial remodeling and epithelial-stromal crosstalk during implantation. Mol Endocrinol. 2013;27:1996-2012 pubmed publisher
Zhang X, Liang X, Wang T, Liang X, Zuo R, Deng W, et al. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Mol Cell Endocrinol. 2013;381:272-9 pubmed publisher
Diaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge S. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol. 2013;201:279-92 pubmed publisher
Nelson C, Ackerman K, O Hayer P, Bailey T, Gorsuch R, Hyde D. Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration. J Neurosci. 2013;33:6524-39 pubmed publisher
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Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, et al. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J Biol Chem. 2007;282:31643-55 pubmed
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Zhu J, Jia X, Xiao G, Kang Y, Partridge N, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem. 2007;282:26656-64 pubmed
Wolff G, Chiang P, Smith S, Romero R, Armant D. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Biol Reprod. 2007;77:53-60 pubmed
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product information

brand :

R&D Systems

master code :

259-HE

SKU :

259-HE-050

product name :

Recombinant Human HB-EGF Protein

description :

The Recombinant Human HB-EGF Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human HB-EGF Protein has been validated for the following applications: Bioactivity.

target :

HB-EGF

category :

Proteins and Enzymes

unit size :

50 ug (also 250 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE with silver staining

species :

Human

observed molecular weight :

11-20 kDa, reducing conditions

theoretical molecular weight :

9.7 kDa

gene symbol :

HBEGF

details of functionality :

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al . (1991) Proc. Natl. Acad. Sci. USA 88 :415. The ED50 for this effect is 0.15-0.75 ng/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

259-HE

accessionNumbers :

Q99075

applications :

Bioactivity

source :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human HB-EGF protein Asp63-Leu148

2020 USD :

179

2021 USD :

179 USD

alt names :

diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor), Dtr, DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor), Dts, DTSF, HBEGF, Hegfl, heparin-binding EGF-like growth factor, heparin-binding epidermal growth factor, proheparin-binding EGF-like growth factor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.