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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human HB-EGF Protein, CF
catalog :
259-HE-050/CF
quantity :
50 ug (also 250 ug)
price :
223 USD
more info or order :
citations: 64
Reference
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Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
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Elsaeidi F, MacPherson P, Mills E, Jui J, Flannery J, Goldman D. Notch Suppression Collaborates with Ascl1 and Lin28 to Unleash a Regenerative Response in Fish Retina, But Not in Mice. J Neurosci. 2018;38:2246-2261 pubmed publisher
Tanaka T, Zhou Y, Ozawa T, Okizono R, Banba A, Yamamura T, et al. Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation. J Biol Chem. 2018;293:2288-2301 pubmed publisher
Kim S, Yang L, Kim S, Lee R, Graham M, Berliner J, et al. Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development. PLoS ONE. 2017;12:e0182566 pubmed publisher
Venkataraman T, Coleman C, Frieman M. Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. J Virol. 2017;91: pubmed publisher
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Gao J, Ulekleiv C, Halstensen T. Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression. J Exp Clin Cancer Res. 2016;35:151 pubmed
Shim J, Sandlund J, Hameed M, Blazer Yost B, Zhou F, Klagsbrun M, et al. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus. Sci Rep. 2016;6:26794 pubmed publisher
Veltmann M, Hollborn M, Reichenbach A, Wiedemann P, Kohen L, Bringmann A. Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0147312 pubmed publisher
Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015;526:583-6 pubmed publisher
Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan I, et al. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. J Clin Invest. 2015;125:3008-26 pubmed publisher
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Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, et al. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol. 2015;135:1771-1780 pubmed publisher
Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, et al. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014;10:e1004451 pubmed publisher
Peterson J, Phelps E, Doll M, Schaal S, Ceresa B. The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis. Invest Ophthalmol Vis Sci. 2014;55:2870-80 pubmed publisher
Cole C, Rushton G, Jayson G, Avizienyte E. Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling. J Biol Chem. 2014;289:10488-501 pubmed publisher
Shi C, Washington M, Chaturvedi R, Drosos Y, Revetta F, Weaver C, et al. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest. 2014;94:409-21 pubmed publisher
Desai T, Brownfield D, Krasnow M. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190-4 pubmed publisher
Scafidi J, Hammond T, Scafidi S, Ritter J, Jablonska B, Roncal M, et al. Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature. 2014;506:230-4 pubmed publisher
Fortian A, Sorkin A. Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis. J Cell Sci. 2014;127:432-44 pubmed publisher
Pawar S, Starosvetsky E, Orvis G, Behringer R, Bagchi I, Bagchi M. STAT3 regulates uterine epithelial remodeling and epithelial-stromal crosstalk during implantation. Mol Endocrinol. 2013;27:1996-2012 pubmed publisher
Zhang X, Liang X, Wang T, Liang X, Zuo R, Deng W, et al. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Mol Cell Endocrinol. 2013;381:272-9 pubmed publisher
Diaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge S. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol. 2013;201:279-92 pubmed publisher
Nelson C, Ackerman K, O Hayer P, Bailey T, Gorsuch R, Hyde D. Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration. J Neurosci. 2013;33:6524-39 pubmed publisher
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Zhu J, Jia X, Xiao G, Kang Y, Partridge N, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem. 2007;282:26656-64 pubmed
Wolff G, Chiang P, Smith S, Romero R, Armant D. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Biol Reprod. 2007;77:53-60 pubmed
Li F, Shetty A, Sugahara K. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways. J Biol Chem. 2007;282:2956-66 pubmed
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Leach R, Kilburn B, Wang J, Liu Z, Romero R, Armant D. Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev Biol. 2004;266:223-37 pubmed
Barbour A, Reeder J, Walsh M, Fawcett J, Antalis T, Gotley D. Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res. 2003;63:887-92 pubmed
product information
master code :
259-HE/CF
SKU :
259-HE-050/CF
product name :
Recombinant Human HB-EGF Protein, CF
unit size :
50 ug (also 250 ug)
description :
The Recombinant Human HB-EGF Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human HB-EGF Protein, CF has been validated for the following applications: Bioactivity.
target :
HB-EGF
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE with silver staining
species :
Human
observed molecular weight :
11-20 kDa, reducing conditions
theoretical molecular weight :
9.7 kDa
gene symbol :
HBEGF
details of functionality :
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al . (1991) Proc. Natl. Acad. Sci. USA 88 :415. The ED50 for this effect is 0.15-0.75 ng/mL.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q99075
applications :
Bioactivity
source long :
Spodoptera frugiperda , Sf 21 (baculovirus)-derived human HB-EGF protein Asp63-Leu148
source short :
Sf 21 (baculovirus)
USD :
223 USD
alt names :
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor), Dtr, DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor), Dts, DTSF, HBEGF, Hegfl, heparin-binding EGF-like growth factor, heparin-binding epidermal growth factor, proheparin-binding EGF-like growth factor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.