Recombinant Human Midkine Protein, CF | R&D Systems 258-MD-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Midkine Protein, CF

catalog :

258-MD-010

quantity :

10 ug (also 50 ug)

price :

351 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Jeffrey D, Pires Da Silva J, Garcia A, Jiang X, Karimpour Fard A, Toni L, et al. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021;6: pubmed publisher
Sun B, Hu C, Yang Z, Zhang X, Zhao L, Xiong J, et al. Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells. Oncotarget. 2017;8:32523-32535 pubmed publisher
Higashi K, Takeuchi Y, Mukuno A, Tomitori H, Miya M, Linhardt R, et al. Composition of glycosaminoglycans in elasmobranchs including several deep-sea sharks: identification of chondroitin/dermatan sulfate from the dried fins of Isurus oxyrinchus and Prionace glauca. PLoS ONE. 2015;10:e0120860 pubmed publisher
Rawnaq T, Dietrich L, Wolters Eisfeld G, Uzunoglu F, Vashist Y, Bachmann K, et al. The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer. Mol Cancer Res. 2014;12:670-80 pubmed publisher
Neunaber C, Catala Lehnen P, Beil F, Marshall R, Kanbach V, Baranowsky A, et al. Increased trabecular bone formation in mice lacking the growth factor midkine. J Bone Miner Res. 2010;25:1724-35 pubmed publisher
Jin Z, Lahat G, Korchin B, Nguyen T, Zhu Q, Wang X, et al. Midkine enhances soft-tissue sarcoma growth: a possible novel therapeutic target. Clin Cancer Res. 2008;14:5033-42 pubmed publisher
Said E, Krust B, Nisole S, Svab J, Briand J, Hovanessian A. The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor. J Biol Chem. 2002;277:37492-502 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

258-MD

SKU :

258-MD-010

product name :

Recombinant Human Midkine Protein, CF

Description :

The Recombinant Human Midkine Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Midkine Protein, CF has been validated for the following applications: Bioactivity.

target :

Midkine

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

13.3 kDa

gene symbol :

MDK

details of functionality :

Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cerebral cortical neurons. Muramatsu, H. and T. Muramatsu (1991) Biochem. Biophys. Res. Commu. 177 :652. Optimal neurite outgrowth was observed when neurons were plated on 96-well culture plates that had been pre-coated with 100 µL/well of a solution of 3.0-8.0 µg/mL of rhMK.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P21741.1

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Midkine Protein

USD :

351 USD

alt names :

Amphiregulin-associated protein, ARAP, MDK, MEK, Midgestation and kidney protein, midkine, midkine (neurite growth-promoting factor 2), MK1, MKARAP, NEGF2, NEGF2FLJ27379, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage