product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Progranulin Protein, CF
catalog :
2557-PG-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Dedert C, Salih L, Xu F. Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling. Cells. 2023;12: pubmed publisher
L xfc tge M, De Martin A, Gil Cruz C, Perez Shibayama C, Stanossek Y, Onder L, et al. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol. 2023;24:1149-1160 pubmed publisher
Liu J, Lai X, Yu R, Ding H, Bai H, Yang Z, et al. Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity. PLoS Pathog. 2022;18:e1010873 pubmed publisher
Dedert C, Mishra V, Aggarwal G, Nguyen A, Xu F. Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress. Front Cell Neurosci. 2022;16:874258 pubmed publisher
Sasaki T, Shimazawa M, Kanamori H, Yamada Y, Nishinaka A, Kuse Y, et al. Effects of progranulin on the pathological conditions in experimental myocardial infarction model. Sci Rep. 2020;10:11842 pubmed publisher
Chen Y, Wang C, Xie K, Lei M, Chai Y, Xu F, et al. Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization. Mediators Inflamm. 2020;2020:9704327 pubmed publisher
Yoo W, Lee J, Noh K, Lee S, Jung D, Kabir M, et al. Progranulin attenuates liver fibrosis by downregulating the inflammatory response. Cell Death Dis. 2019;10:758 pubmed publisher
Wang X, Yuan J, Wang H, Gan N, Zhang Q, Liu B, et al. Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection. J Immunol. 2019;203:2171-2182 pubmed publisher
Elia L, Mason A, Alijagic A, Finkbeiner S. Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway. J Neurosci. 2019;39:3332-3344 pubmed publisher
Quaranta V, Rainer C, Nielsen S, Raymant M, Ahmed M, Engle D, et al. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018;78:4253-4269 pubmed publisher
Arrant A, Onyilo V, Unger D, Roberson E. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. J Neurosci. 2018;38:2341-2358 pubmed publisher
Nielsen S, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, et al. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol. 2016;18:549-60 pubmed publisher
Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, et al. Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina. Sci Rep. 2016;6:23811 pubmed publisher
product information
master code :
2557-PG
SKU :
2557-PG-050
product name :
Recombinant Mouse Progranulin Protein, CF
unit size :
50 ug
description :
The Recombinant Mouse Progranulin Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Progranulin Protein, CF has been validated for the following applications: Bioactivity.
target :
Progranulin/PGRN
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
80-90 kDa, reducing conditions
theoretical molecular weight :
62.4 kDa
gene symbol :
Grn
details of functionality :
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Able to significantly enhance neurite outgrowth when immobilized at 4-16 ╡g/mL on a nitrocellulose-coated microplate.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P28798
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived mouse Progranulin/PGRN protein Thr18-Leu589, with a C-terminal 6-His tag
source short :
NS0
USD :
432 USD
alt names :
Acrogranin, CLN11, GEP, GP88, granulin precursor, GRN, PCDGF, PEPI, PGRN, Proepithelin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.