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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Osteoactivin/GPNMB Fc Chimera Protein, CF
catalog :
2550-AC-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Wang Q, Kuroda Y, Yang L, Lai S, Mizutani Y, Iddamalgoda A, et al. GPNMB Extracellular Fragment Protects Melanocytes from Oxidative Stress by Inhibiting AKT Phosphorylation Independent of CD44. Int J Mol Sci. 2021;22: pubmed publisher
Prabata A, Ikeda K, Rahardini E, Hirata K, Emoto N. GPNMB plays a protective role against obesity-related metabolic disorders by reducing macrophage inflammatory capacity. J Biol Chem. 2021;297:101232 pubmed publisher
Neal M, Boyle A, Budge K, Safadi F, Richardson J. The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor. J Neuroinflammation. 2018;15:73 pubmed publisher
Ma J, Baker A, Calabro A, Derwin K. Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model. PLoS ONE. 2017;12:e0175853 pubmed publisher
Ono Y, Tsuruma K, Takata M, Shimazawa M, Hara H. Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase. Sci Rep. 2016;6:23241 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
2550-AC
SKU :
2550-AC-050
product name :
Recombinant Human Osteoactivin/GPNMB Fc Chimera Protein, CF
description :
The Recombinant Human Osteoactivin/GPNMB Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Osteoactivin/GPNMB Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Osteoactivin/GPNMB
unit size :
50 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
115-125 kDa, reducing conditions
theoretical molecular weight :
78.6 kDa (monomer)
gene symbol :
GPNMB
details of functionality :
Measured by the ability of the immobilized protein to induce pro-MMP-9 secretion by NHLF human normal lung fibroblasts The ED50 for this effect is 2.5-10 µg/mL. Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_002501
applications :
Bioactivity
product keywords :
2550-AC, rhOsteoactivin/Fc, hOsteoactivin, carrier-free, carrier free, 255O-AC, 2550AC, NMB, Q14956
source :
NS0-derived Recombinant Human Osteoactivin/GPNMB Fc Chimera Protein, CF
USD :
423
USD 2025 :
432 USD
alt names :
DC-HIL, glycoprotein (transmembrane) nmb, glycoprotein NMB, GPNMB, HGFIN, HGFINglycoprotein nmb-like protein, NMBosteoactivin, Transmembrane glycoprotein HGFIN, transmembrane glycoprotein NMB
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.