Recombinant Human FGF-21 Protein, CF | R&D Systems 2539-FG-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FGF-21 Protein, CF

catalog :

2539-FG-025/CF

quantity :

25 ug

price :

351 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez E, et al. FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. Sci Rep. 2022;12:7326 pubmed publisher
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, et al. Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 2017;127:3496-3509 pubmed publisher
Dunshee D, Bainbridge T, Kljavin N, Zavala Solorio J, Schroeder A, Chan R, et al. Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21. J Biol Chem. 2016;291:5986-96 pubmed publisher
Comps Agrar L, Dunshee D, Eaton D, Sonoda J. Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem. 2015;290:24166-77 pubmed publisher
Smith R, O Bryan L, Farrow E, Summers L, Clinkenbeard E, Roberts J, et al. Circulating ?Klotho influences phosphate handling by controlling FGF23 production. J Clin Invest. 2012;122:4710-5 pubmed publisher
Wu A, Coulter S, Liddle C, Wong A, Eastham Anderson J, French D, et al. FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS ONE. 2011;6:e17868 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher

image

image 1 :

Recombinant Human FGF-21 Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

2539-FG/CF

SKU :

2539-FG-025/CF

product name :

Recombinant Human FGF-21 Protein, CF

Description :

The Recombinant Human FGF-21 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human FGF-21 Protein, CF has been validated for the following applications: Bioactivity.

target :

FGF-21

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES, Na2SO4, EDTA and DTT.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

24 kDa, reducing conditions

theoretical molecular weight :

20.2 kDa

gene symbol :

FGF21

details of functionality :

Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGF RIIIc. The ED50 for this effect is 0.06-0.4 µg/mL in the presence of Recombinant Mouse Klotho beta (Catalog # 2619-KB ).

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9NSA1

applications :

Bioactivity

source :

E. coli-derived Recombinant Human FGF-21 Protein

USD :

351 USD

alt names :

FGF21, FGF-21, fibroblast growth factor 21

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage