Recombinant Human Integrin alpha V beta 5 Protein, CF | R&D Systems 2528-AV-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha V beta 5 Protein, CF

catalog :

2528-AV-050

quantity :

50 ug

price :

503 USD

citations: 8

Reference
Calver J, Parmar N, Harris G, Lithgo R, Stylianou P, Zetterberg F, et al. Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis. J Biol Chem. 2024;300:107300 pubmed publisher
Bieri M, Hendrickx R, Bauer M, Yu B, Jetzer T, Dreier B, et al. The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathog. 2021;17:e1010083 pubmed publisher
Shin S, Kim J, Park S, Jun S, Kweon H, Choi D, et al. Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth. Sci Adv. 2020;6:eaay2174 pubmed publisher
Bhatnagar S, Khera E, Liao J, Eniola V, Hu Y, Smith D, et al. Oral and Subcutaneous Administration of a Near-Infrared Fluorescent Molecular Imaging Agent Detects Inflammation in a Mouse Model of Rheumatoid Arthritis. Sci Rep. 2019;9:4661 pubmed publisher
Koh K, Cao Y, Mangos S, Tardi N, Dande R, Lee H, et al. Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. J Clin Invest. 2019;129:1713-1726 pubmed publisher
Whilding L, Parente Pereira A, Zabinski T, Davies D, Petrovic R, Kao Y, et al. Targeting of Aberrant Î±vÎ²6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells. Mol Ther. 2017;25:259-273 pubmed publisher
Bönig T, Olbermann P, Bats S, Fischer W, Josenhans C. Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci Rep. 2016;6:38101 pubmed publisher
Kwon I, Hong S, Kim Y, Nam H, Kang S, Yang S, et al. Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice. PLoS ONE. 2013;8:e81165 pubmed publisher

product information

master code :

2528-AV

SKU :

2528-AV-050

product name :

Recombinant Human Integrin alpha V beta 5 Protein, CF

unit size :

50 ug

description :

The Recombinant Human Integrin alpha V beta 5 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha V beta 5 Protein, CF has been validated for the following applications: Bioactivity.

target :

Integrin alpha V beta 5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

100-155 kDa, reducing conditions

theoretical molecular weight :

115.4 kDa ( alpha V subunit) 84.8 kDa (▀5 subunit)

gene symbol :

ITGAV

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human Vitronectin (Catalog # 2308-VN ) is coated at 1 ╡g/mL, Recombinant Human Integrin alpha V▀5 binds with an apparent KD 0.5 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P06756 (Integrin alpha V) P18084 (Integrin ▀5)

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived human Integrin alpha V beta 5 protein Human Integrin alpha V (Phe31-Val992) Accession # P06756 His-Pro GGGSGGGS Acidic Tail 6-His tag Human Integrin ▀5 (Gly24-Asn719) Accession # P18084 His-Pro GGGSGGGS Basic Tail N-terminus C-terminus

source short :

CHO

USD :

503 USD

alt names :

CD51, integrin subunit alpha V, ITGAV, MSK8, VNRA, VTNR

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.