Recombinant Human Pleiotrophin/PTN Protein, CF | R&D Systems 252-PL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Pleiotrophin/PTN Protein, CF

catalog :

252-PL-050

quantity :

50 ug

price :

334 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Liu S, Shen M, Hsu E, Zhang C, García Marqués F, Nolley R, et al. Discovery of PTN as a serum-based biomarker of pro-metastatic prostate cancer. Br J Cancer. 2021;124:896-900 pubmed publisher
Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, et al. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Sci Signal. 2016;9:ra103 pubmed
Nandi S, Cioce M, Yeung Y, Nieves E, Tesfa L, Lin H, et al. Receptor-type protein-tyrosine phosphatase ? is a functional receptor for interleukin-34. J Biol Chem. 2013;288:21972-86 pubmed publisher
Chen H, Campbell R, Chang Y, Li M, Wang C, Li J, et al. Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. Blood. 2009;113:1992-2002 pubmed publisher
Chen H, Gordon M, Campbell R, Li M, Wang C, Lee H, et al. Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth. Blood. 2007;110:287-95 pubmed

product information

brand :

R&D Systems

master code :

252-PL

SKU :

252-PL-050

product name :

Recombinant Human Pleiotrophin/PTN Protein, CF

unit size :

50 ug

description :

GluN2C/GluN2D-selective NMDA antagonist

target :

Pleiotrophin/PTN

category :

Proteins and Enzymes

alt names :

HARP, HBBM, HB-GAM, HBGF8, HBNF, HBNF1, HBNF-1, Heparin-binding brain mitogen, HNGF-8, NEGF1HBGF-8, neurite growth-promoting factor 1, neurite growth-promoting factor1), OSF-1, Osteoblast-specific factor 1, pleiotrophin, PTN

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

18 kDa, reducing conditions

theoretical molecular weight :

15.3 kDa

gene symbol :

PTN

details of functionality :

Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cerebral cortical neurons. Muramatsu, H. and T. Muramatsu (1991) Biochem. Biophys. Res. Commu. 177 :652. Optimal neurite outgrowth was observed when neurons were plated on 96 well culture plates that had been pre-coated with 100 µL/well of a solution of 3-8 µg/mL rhPTN.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q6ICQ5

applications :

Bioactivity

source :

Sf 21 (baculovirus)-derived Recombinant Human Pleiotrophin/PTN Protein, CF

USD :

309

Jul-22 :

334 USD

sizes available :

50 ug (also 250 ug)

more info or order :

R&D Systems product webpage