product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Pappalysin-1/PAPP-A (aa 82-1627), CF
catalog :
2487-ZNF-020
quantity :
20 ug
price :
525 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Li W, Li H, Zhou L, Wang Z, Hua B. Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways. Mediators Inflamm. 2019;2019:8436985 pubmed publisher
Jayabal P, Houghton P, Shiio Y. EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1. Genes Cancer. 2017;8:762-770 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
2487-ZNF
SKU :
2487-ZNF-020
product name :
Recombinant Human Pappalysin-1/PAPP-A (aa 82-1627), CF
Description :
The Recombinant Human Pappalysin-1/PAPP-A (aa 82-1627), CF from R&D Systems is derived from NS0. The Recombinant Human Pappalysin-1/PAPP-A (aa 82-1627), CF has been validated for the following applications: Enzyme Activity.
target :
Pappalysin-1/PAPP-A
category :
Proteins and Enzymes
unit size :
20 ug
buffer :
Supplied as a 0.2 µm filtered solution in Tris, NaCl, CaCl2, and CHAPS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
139-238 kDa, three bands, reducing conditions
theoretical molecular weight :
173 kDa
gene symbol :
PAPPA
details of functionality :
Measured by its ability to cleave IGFBP-5. Recombinant Human Pappalysin-1/PAPP-A will cleave 75% of Recombinant Human IGFBP-5 (Catalog # 875-B5 ), as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q13219
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Pappalysin-1/PAPP-A (aa 82-1627)
USD :
525 USD
alt names :
ASBABP2, DIPLA1, EC 3.4.24.79, IGFBP-4ase, IGFBP-4aseaspecific BCL2 ARE-binding protein 2, IGF-dependent IGFBP-4 protease, insulin-like growth factor-dependent IGF binding protein-4 protease, Insulin-like growth factor-dependent IGF-binding protein 4 protease, PAPA, PAPPA, PAPPA1, PAPP-A1, PAPP-Adifferentially placenta 1 expressed protein, pappalysin-1, Pappalysin1, pregnacy-associated plasma protein A, Pregnancy-associated plasma protein A, pregnancy-associated plasma protein A, pappalysin 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.