Recombinant Human TfR Protein, CF | R&D Systems 2474-TR-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TfR Protein, CF

catalog :

2474-TR-050

quantity :

50 ug

price :

468 USD

citations: 6

Reference
Bratti M, Stubbs E, Kolodych S, Souchet H, Kelly L, Merlin J, et al. INA03: A Potent Transferrin-Competitive Antibody-Drug Conjugate against CD71 for Safer Acute Leukemia Treatment. Mol Cancer Ther. 2024;23:1159-1175 pubmed publisher
Ru xe9 L, Jaspers T, Degors I, Noppen S, Schols D, De Strooper B, et al. Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics. 2023;15: pubmed publisher
Cohen C, Coulon S, Bhukhai K, Neuraz A, Dussiot M, Fouquet G, et al. Erythrocytosis associated with IgA nephropathy. EBioMedicine. 2022;75:103785 pubmed publisher
Guan J, Liu X, Zhang H, Lv Y, Wang X, Yang X, et al. Generation of an iPSC line (SDQLCHi015-A) from peripheral blood mononuclear cells of a patient with mental retardation type 15 carrying c.1007_1011del, p.(Ile336fs) in CUL4B gene. Stem Cell Res. 2019;41:101628 pubmed publisher
García Valdés L, Campoy C, Hayes H, Florido J, Rusanova I, Miranda M, et al. The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy. Int J Obes (Lond). 2015;39:571-8 pubmed publisher
Sade H, Baumgartner C, Hugenmatter A, Moessner E, Freskgård P, Niewoehner J. A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding. PLoS ONE. 2014;9:e96340 pubmed publisher

product information

master code :

2474-TR

SKU :

2474-TR-050

product name :

Recombinant Human TfR Protein, CF

unit size :

50 ug

description :

The Recombinant Human TfR Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TfR Protein, CF has been validated for the following applications: Bioactivity.

target :

TfR (Transferrin R)

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

76-85 kDa, reducing conditions

theoretical molecular weight :

76 kDa

gene symbol :

TFRC

details of functionality :

Measured by its binding ability in a functional ELISA. When human Holo-Transferrin (Catalog # 2914-HT) is coated at 0.5 ╡g/mL (100 ╡L/well), the concentration of rhTfR that produces 50% of the optimal binding response is found to be approximately 3-12 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Graph showing dose-dependent bioactivity of Human TfR protein

accessionNumbers :

CAA25527

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human TfR (Transferrin R) protein Cys89-Phe760, with an N-terminal 6-His tag

source short :

NS0

USD :

468 USD

alt names :

CD71, CD71 antigen, CD71TRFR, p90, T9, TfR, TfR (TransferrinR), TFR1, TFRC, TR, transferrin receptor (p90, CD71), transferrin receptor protein 1, Trfr

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.