Recombinant Human RGM-A Protein, CF | R&D Systems 2459-RM-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human RGM-A Protein, CF

catalog :

2459-RM-050

quantity :

50 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, et al. RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS. Sci Adv. 2023;9:eadg3193 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
Isakova I, Baker K, DuTreil M, Dufour J, Gaupp D, Phinney D. Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells. 2007;25:3261-70 pubmed

product information

master code :

2459-RM

SKU :

2459-RM-050

product name :

Recombinant Human RGM-A Protein, CF

unit size :

50 ug

description :

The Recombinant Human RGM-A Protein, CF from R&D Systems is derived from NS0. The Recombinant Human RGM-A Protein, CF has been validated for the following applications: Binding Activity.

target :

RGM-A

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

Multiple bands between 25-37 kDa, reducing conditions

theoretical molecular weight :

42.4 kDa

gene symbol :

RGMA

details of functionality :

Measured by its binding ability in a functional ELISA. When rhBMP-4 is coated at 1 ╡g/mL, rhRGM-A binds with an apparent KD 50nM. Immobilized rhRGM-A can bind rmNeogenin/Fc Chimera with a linear range of 10-500 ng/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q96B86

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human RGM-A protein Cys48-Gly422 & Pro169-Gly422, both with a C-terminal 6-His tag

source short :

NS0

USD :

456 USD

alt names :

RGM domain family member A, RGM domain family, member A, RGMA, RGMrepulsive guidance molecule A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage