Recombinant Human Progranulin Protein, CF | R&D Systems 2420-PG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Progranulin Protein, CF

catalog :

2420-PG

quantity :

50 ug

price :

339 USD

citations: 11

Reference
Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, et al. Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma. Endocr J. 2020;67:91-94 pubmed publisher
Mendsaikhan A, Tooyama I, Bellier J, Serrano G, Sue L, Lue L, et al. Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun. 2019;7:215 pubmed publisher
Yoo W, Lee J, Noh K, Lee S, Jung D, Kabir M, et al. Progranulin attenuates liver fibrosis by downregulating the inflammatory response. Cell Death Dis. 2019;10:758 pubmed publisher
Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, et al. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018;9:433 pubmed publisher
Altmann C, Vasic V, Hardt S, Heidler J, Häussler A, Wittig I, et al. Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling. Mol Neurodegener. 2016;11:69 pubmed
Abdiche Y, Miles A, Eckman J, Foletti D, Van Blarcom T, Yeung Y, et al. High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity. PLoS ONE. 2014;9:e92451 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
Elkabets M, Gifford A, Scheel C, Nilsson B, Reinhardt F, Bray M, et al. Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest. 2011;121:784-99 pubmed publisher
Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, et al. Serum biomarker for progranulin-associated frontotemporal lobar degeneration. Ann Neurol. 2009;65:603-9 pubmed publisher
Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, et al. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol. 2008;181:37-41 pubmed publisher

product information

brand :

R&D Systems

master code :

2420-PG

SKU :

2420-PG-050

product name :

Recombinant Human Progranulin Protein, CF

description :

The Recombinant Human Progranulin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Progranulin Protein, CF has been validated for the following applications: Bioactivity.

target :

Progranulin/PGRN

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

90-95 kDa

theoretical molecular weight :

62.6 kDa

gene symbol :

GRN

details of functionality :

Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant Human Progranulin/PGRN, immobilized at 10-40 µg/mL on a nitrocellulose coated plate, is able to significantly enhance neurite outgrowth.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

2420-PG

accessionNumbers :

P28799

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human Progranulin/PGRN protein Thr18-Leu593, with a C-terminal 6-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

Acrogranin, CLN11, GEP, GP88, granulin precursor, GRN, PCDGF, PEPI, PGRN, Proepithelin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.