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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Progranulin Protein, CF
catalog :
2420-PG-050
quantity :
50 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
L xfc tge M, De Martin A, Gil Cruz C, Perez Shibayama C, Stanossek Y, Onder L, et al. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol. 2023;24:1149-1160 pubmed publisher
Tran L, Graulus G, Vincke C, Smiejkowska N, Kindt A, Devoogdt N, et al. Nanobodies for the Early Detection of Ovarian Cancer. Int J Mol Sci. 2022;23: pubmed publisher
Zambusi A, Novoselc K, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, et al. TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nat Neurosci. 2022;25:1608-1625 pubmed publisher
Liu J, Lai X, Yu R, Ding H, Bai H, Yang Z, et al. Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity. PLoS Pathog. 2022;18:e1010873 pubmed publisher
Monteys A, Hundley A, Ranum P, Tecedor L, Muehlmatt A, Lim E, et al. Regulated control of gene therapies by drug-induced splicing. Nature. 2021;596:291-295 pubmed publisher
Tian D, Qin Q, Li M, Li X, Xu Q, Lv Q. Homocysteine Impairs Endothelial Cell Barrier Function and Angiogenic Potential via the Progranulin/EphA2 Pathway. Front Pharmacol. 2020;11:614760 pubmed publisher
Gururaj S, Sampognaro P, Argouarch A, Kao A. Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics. Front Neurosci. 2020;14:602235 pubmed publisher
Feng D, Kang X, Wang R, Chen H, Zhang K, Feng W, et al. Progranulin modulates cartilage-specific gene expression via sirtuin 1-mediated deacetylation of the transcription factors SOX9 and P65. J Biol Chem. 2020;295:13640-13650 pubmed publisher
Yoo W, Lee J, Noh K, Lee S, Jung D, Kabir M, et al. Progranulin attenuates liver fibrosis by downregulating the inflammatory response. Cell Death Dis. 2019;10:758 pubmed publisher
Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, et al. Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcoma. Endocr J. 2020;67:91-94 pubmed publisher
Schulze Edinghausen L, Dürr C, Oztürk S, Zucknick M, Benner A, Kalter V, et al. Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. Cancers (Basel). 2019;11: pubmed publisher
Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, et al. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018;9:433 pubmed publisher
Altmann C, Vasic V, Hardt S, Heidler J, Häussler A, Wittig I, et al. Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling. Mol Neurodegener. 2016;11:69 pubmed
Abdiche Y, Miles A, Eckman J, Foletti D, Van Blarcom T, Yeung Y, et al. High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity. PLoS ONE. 2014;9:e92451 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Suh H, Choi N, Tarassishin L, Lee S. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PLoS ONE. 2012;7:e35115 pubmed publisher
Elkabets M, Gifford A, Scheel C, Nilsson B, Reinhardt F, Bray M, et al. Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest. 2011;121:784-99 pubmed publisher
Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, et al. Serum biomarker for progranulin-associated frontotemporal lobar degeneration. Ann Neurol. 2009;65:603-9 pubmed publisher
Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, et al. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol. 2008;181:37-41 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
2420-PG
SKU :
2420-PG-050
product name :
Recombinant Human Progranulin Protein, CF
Description :
The Recombinant Human Progranulin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Progranulin Protein, CF has been validated for the following applications: Bioactivity.
target :
Progranulin/PGRN
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
90-95 kDa
theoretical molecular weight :
62.6 kDa
gene symbol :
GRN
details of functionality :
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant Human Progranulin/PGRN, immobilized at 10-40 µg/mL on a nitrocellulose coated plate, is able to significantly enhance neurite outgrowth.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P28799
applications :
Bioactivity
source :
NS0-derived Recombinant Human Progranulin Protein
USD :
423 USD
alt names :
Acrogranin, CLN11, GEP, GP88, granulin precursor, GRN, PCDGF, PEPI, PGRN, Proepithelin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.