Recombinant Human TGF-beta RIII Protein | R&D Systems 242-R3 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TGF-beta RIII Protein

catalog :

242-R3

quantity :

100 ug

price :

569 USD

citations: 6

Reference
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Graham J, Chamberland A, Lin Q, Li X, Dai D, Zeng W, et al. Serine protease HTRA1 antagonizes transforming growth factor-? signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS ONE. 2013;8:e74094 pubmed publisher
Florio P, Ciarmela P, Reis F, Toti P, Galleri L, Santopietro R, et al. Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. Eur J Endocrinol. 2005;152:277-84 pubmed
Rosado E, Schwartz Z, Sylvia V, Dean D, Boyan B. Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. Biochim Biophys Acta. 2002;1590:1-15 pubmed
Bandyopadhyay A, Zhu Y, Malik S, Kreisberg J, Brattain M, Sprague E, et al. Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene. 2002;21:3541-51 pubmed

product information

brand :

R&D Systems

master code :

242-R3

SKU :

242-R3-100

product name :

Recombinant Human TGF-beta RIII Protein

description :

The Recombinant Human TGF-beta RIII Protein from R&D Systems is derived from NS0. The Recombinant Human TGF-beta RIII Protein has been validated for the following applications: Bioactivity.

target :

TGF-beta RIII

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

100-190 kDa, reducing conditions

theoretical molecular weight :

84 kDa

gene symbol :

TGFBR3

details of functionality :

Measured by its ability to inhibit TGF-beta 2 activity on HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 20-50 ng/mL in the presence of 0.4 ng/mL of rhTGF-beta 2.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

242-R3

accessionNumbers :

AAA67061.1

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human TGF-beta RIII protein Gly21-Asp781

2020 USD :

569

2021 USD :

569 USD

alt names :

betaglycan, betaglycan proteoglycan, BGCAN, TBRIII, TGF-beta receptor type 3, TGF-beta receptor type III, TGFbetaRIII, TGFBR3, TGF-bRIII, TGFR-3, Transforming growth factor beta receptor III, transforming growth factor beta receptor type 3, transforming growth factor, beta receptor III, transforming growth factor, beta receptor III (betaglycan, 300kDa)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.