Recombinant Human TGF-beta RII Protein, CF | R&D Systems 241-R2-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TGF-beta RII Protein, CF

catalog :

241-R2-025/CF

quantity :

25 ug

price :

470 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Wang S, Feng Y, Feng S, Wu J, Zhang M, Xu W, et al. IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022;43:2542-2549 pubmed publisher
Graham J, Chamberland A, Lin Q, Li X, Dai D, Zeng W, et al. Serine protease HTRA1 antagonizes transforming growth factor-? signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS ONE. 2013;8:e74094 pubmed publisher
Van Aarsen L, Leone D, Ho S, Dolinski B, McCoon P, Lepage D, et al. Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res. 2008;68:561-70 pubmed publisher
Fazzini M, Vallejo G, Colman Lerner A, Trigo R, Campo S, Barañao J, et al. Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. J Cell Physiol. 2006;207:40-8 pubmed
Rosado E, Schwartz Z, Sylvia V, Dean D, Boyan B. Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. Biochim Biophys Acta. 2002;1590:1-15 pubmed

image

image 1 :

Graph showing dose-dependent bioactivity of human TGF-beta RII protein

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

241-R2/CF

SKU :

241-R2-025/CF

product name :

Recombinant Human TGF-beta RII Protein, CF

Description :

The Recombinant Human TGF-beta RII Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TGF-beta RII Protein, CF has been validated for the following applications: Bioactivity.

target :

TGF-beta RII

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

Multiple bands between 20-35 kDa, reducing conditions

theoretical molecular weight :

15 kDa

gene symbol :

TGFBR2

details of functionality :

Measured by its ability to inhibit TGF-beta 1 activity on HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 1-3 µg/mL in the presence of 0.25 ng/mL of recombinant human TGF-beta 1.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P37173.2

applications :

Bioactivity

source :

NS0-derived Recombinant Human TGF-beta RII Protein

USD :

470 USD

alt names :

AAT3, EC 2.7.11, EC 2.7.11.30, FAA3, HNPCC6, LDS1B, LDS2B, MFS2, RIIC, TAAD2, tbetaR-II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGF-beta receptor type-2, TGF-beta type II receptor, TGFbetaRII, TGFbeta-RII, TGFBR2, TGF-bRII, TGFR-2, transforming growth factor beta receptor type IIC, transforming growth factor, beta receptor II (70/80kDa), transforming growth factor, beta receptor II (70/80kDa) isoform 1, transforming growth factor, beta receptor II (70/80kDa) isoform 2, transforming growth factor, beta receptor II (70-80kD), Transforming growth factor-beta receptor type II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage