Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF | R&D Systems 2406-BR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF

catalog :

2406-BR-100

quantity :

100 ug

price :

540 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Srole D, Jung G, Waring A, Nemeth E, Ganz T. Characterization of erythroferrone structural domains relevant to its iron-regulatory function. J Biol Chem. 2023;299:105374 pubmed publisher
Mang T, Kleinschmidt Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A. BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation. J Cell Sci. 2020;133: pubmed publisher

product information

master code :

2406-BR

SKU :

2406-BR-100

product name :

Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

BMPR-IA/ALK-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

59 kDa, reducing conditions

theoretical molecular weight :

40.8 kDa (monomer)

gene symbol :

BMPR1A

details of functionality :

Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.03-0.12 ╡g/mL in the presence of 15 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_004320

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human BMPR-IA/ALK-3 protein Human BMPR-IA (Met1-Arg152) Accession # NP_004320 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

540 USD

alt names :

ACVRLK310q23del, ALK-3, ALK3EC 2.7.11.30, BMP type-1A receptor, BMPR1A, BMPR-1A, BMPRIA, bone morphogenetic protein receptor type-1A, bone morphogenetic protein receptor, type IA, CD292, CD292 antigen, EC 2.7.11, Serine/threonine-protein kinase receptor R5, SKR5, type II-like kinase 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage