Recombinant Human DDR1 Fc Chimera Protein, CF | R&D Systems 2396-DR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human DDR1 Fc Chimera Protein, CF

catalog :

2396-DR-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Wang J, Xie S, Li N, Zhang T, Yao W, Zhao H, et al. Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis. Bioact Mater. 2022;17:406-424 pubmed publisher
Moll S, Yasui Y, Abed A, Murata T, Shimada H, Maeda A, et al. Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime. J Transl Med. 2018;16:148 pubmed publisher
An B, Abbonante V, Xu H, Gavriilidou D, Yoshizumi A, Bihan D, et al. Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor. J Biol Chem. 2016;291:4343-55 pubmed publisher
Aguilera K, Rivera L, Hur H, Carbon J, Toombs J, Goldstein C, et al. Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res. 2014;74:1032-44 pubmed publisher
Hachehouche L, Chetoui N, Aoudjit F. Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen. Mol Immunol. 2010;47:1866-9 pubmed publisher

product information

master code :

2396-DR

SKU :

2396-DR-050

product name :

Recombinant Human DDR1 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human DDR1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human DDR1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

DDR1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

90-95 kDa, reducing conditions

theoretical molecular weight :

70.5 kDa (monomer)

gene symbol :

DDR1

details of functionality :

Measured by its ability to bind Collagen I in a functional ELISA. Leitinger, B. (2003) J. Biol. Chem. 278 :16761. Immobilized Collagen I at 10 ╡g/mL (100 ╡L/well) can bind rhDDR1 with an apparent KD 10 nM. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q5ST11

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human DDR1 protein Human DDR1 (Asp21 - Thr416) Accession # Q5ST11 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

CAK, CD167 antigen-like family member A, CD167a, CD167a antigen, DDR, discoidin domain receptor family, member 1, discoidin domain receptor tyrosine kinase 1, Discoidin receptor tyrosine kinase, EC 2.7.10, EC 2.7.10.1, EDDR1, ENTRK4, Epithelial discoidin domain receptor 1, HGK2, MCK10, MCK-10, NTRK4, Protein-tyrosine kinase 3A, PTK3A, PTK3A protein tyrosine kinase 3A, receptor, type 4, RTK6, TRK E, TrkE

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage