This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TGF-alpha Protein, CF
catalog :
239-A
quantity :
100 ug (also 500 ug)
price :
329 USD
citations: 42
Reference |
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Jia H, Ma X, Tong W, Doyran B, Sun Z, Wang L, et al. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation. Proc Natl Acad Sci U S A. 2016;113:14360-14365 pubmed
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Garcia B, Neninger E, de la Torre A, Leonard I, Martínez R, Viada C, et al. Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth fa. Clin Cancer Res. 2008;14:840-6 pubmed publisher
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Zhu J, Jia X, Xiao G, Kang Y, Partridge N, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem. 2007;282:26656-64 pubmed
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Wolff G, Chiang P, Smith S, Romero R, Armant D. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Biol Reprod. 2007;77:53-60 pubmed
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Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed
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Li Y, Fan J, Chen M, Li W, Woodley D. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J Invest Dermatol. 2006;126:2096-105 pubmed
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Rhodes K, Raivich G, Fawcett J. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience. 2006;140:87-100 pubmed
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Ni Z, Okeley N, Smart B, Gelb M. Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells. J Biol Chem. 2006;281:16245-55 pubmed
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Baginski T, Dabbagh K, Satjawatcharaphong C, Swinney D. Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli. Am J Respir Cell Mol Biol. 2006;35:165-74 pubmed
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Armant D, Kilburn B, Petkova A, Edwin S, Duniec Dmuchowski Z, Edwards H, et al. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development. 2006;133:751-9 pubmed
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Schmidt Ott K, Yang J, Chen X, Wang H, Paragas N, Mori K, et al. Novel regulators of kidney development from the tips of the ureteric bud. J Am Soc Nephrol. 2005;16:1993-2002 pubmed
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Beer H, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, et al. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene. 2005;24:5269-77 pubmed
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Snodgrass Belt P, Gilbert J, Davis F. Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters. Brain Res. 2005;1038:171-82 pubmed
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Nagineni C, Kutty V, Detrick B, Hooks J. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J Cell Physiol. 2005;203:35-43 pubmed
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Leach R, Kilburn B, Wang J, Liu Z, Romero R, Armant D. Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev Biol. 2004;266:223-37 pubmed
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product information
brand :
R&D Systems
master code :
239-A
SKU :
239-A-100
product name :
Recombinant Human TGF-alpha Protein, CF
description :
The Recombinant Human TGF-alpha Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human TGF-alpha Protein, CF has been validated for the following applications: Bioactivity.
target :
TGF-alpha
category :
Proteins and Enzymes
unit size :
100 ug (also 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
theoretical molecular weight :
6 kDa
gene symbol :
TGFA
details of functionality :
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Marquardt, H. et al . (1984) Science 223 :1079. The ED50 for this effect is 0.1-0.4 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
239-A
accessionNumbers :
P01135
applications :
Bioactivity
source :
E. coli -derived human TGF-alpha protein Val40-Ala89
2020 USD :
329
2021 USD :
329 USD
alt names :
protransforming growth factor alpha, TFGA, TGFA, TGFalpha, transforming growth factor, alpha, transforming growth factor-alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information

R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.
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