Recombinant Human LRP-1 Cluster II Fc Chimera Protein, CF | R&D Systems 2368-L2-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human LRP-1 Cluster II Fc Chimera Protein, CF

catalog :

2368-L2-050

quantity :

50 ug

price :

438 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Toldo S, Austin D, Mauro A, Mezzaroma E, Van Tassell B, Marchetti C, et al. Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction. JACC Basic Transl Sci. 2017;2:561-574 pubmed publisher
Ruan H, Chai Z, Shen Q, Chen X, Su B, Xie C, et al. A novel peptide ligand RAP12 of LRP1 for glioma targeted drug delivery. J Control Release. 2018;279:306-315 pubmed publisher
Sakamoto K, Shinohara T, Adachi Y, Asami T, Ohtaki T. A novel LRP1-binding peptide L57 that crosses the blood brain barrier. Biochem Biophys Rep. 2017;12:135-139 pubmed publisher
Young P, Migliorini M, Strickland D. Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE. J Biol Chem. 2016;291:26035-26044 pubmed
Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, et al. Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities. PLoS ONE. 2014;9:e103839 pubmed publisher
Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, et al. A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration. Arterioscler Thromb Vasc Biol. 2013;33:935-42 pubmed publisher

product information

brand :

R&D Systems

master code :

2368-L2

SKU :

2368-L2-050

product name :

Recombinant Human LRP-1 Cluster II Fc Chimera Protein, CF

description :

The Recombinant Human LRP-1 Cluster II Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human LRP-1 Cluster II Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

LRP-1 Cluster II

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

90-100 kDa, reducing conditions

theoretical molecular weight :

68.1 kDa

gene symbol :

LRP1

details of functionality :

Measured by its binding ability in a functional ELISA. When rhLRP-1C2/Fc Chimera is immobilized at 50 ng/mL (100 µL/well), the concentration of rhLRPAP (Catalog # 4296-LR) that produces 50% of the optimal binding response is found to be approximately 0.5-2.5 ng/mL.

endotoxin note :

<0.1 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q07954

applications :

Binding Activity

source :

NS0-derived Recombinant Human LRP-1 Cluster II Fc Chimera Protein, CF

USD :

431

USD 2023 :

438 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage