Recombinant Human TIM-3 Fc Chimera Protein, CF | R&D Systems 2365-TM-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TIM-3 Fc Chimera Protein, CF

catalog :

2365-TM-050

quantity :

50 ug

price :

405 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Lake C, Voss K, Bauman B, Pohida K, Jiang T, Dveksler G, et al. TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8+ T cells in conjunction with CEACAM1. Cell Death Dis. 2021;12:400 pubmed publisher
Riva A, Palma E, Devshi D, Corrigall D, Adams H, Heaton N, et al. Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity. Front Physiol. 2021;12:632502 pubmed publisher
de Kivit S, Kostadinova A, Kerperien J, Morgan M, Muruzabal V, Hofman G, et al. Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation. J Leukoc Biol. 2017;102:105-115 pubmed publisher
Wang S, Cao C, Piao H, Li Y, Tao Y, Zhang X, et al. Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface. Sci Rep. 2015;5:9013 pubmed publisher
Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
Kojima R, Ohno T, Iikura M, Niki T, Hirashima M, Iwaya K, et al. Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line. PLoS ONE. 2014;9:e86106 pubmed publisher
Leitner J, Rieger A, Pickl W, Zlabinger G, Grabmeier Pfistershammer K, Steinberger P. TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 2013;9:e1003253 pubmed publisher
Nebbia G, Peppa D, Schurich A, Khanna P, Singh H, Cheng Y, et al. Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS ONE. 2012;7:e47648 pubmed publisher
Wu W, Shi Y, Li S, Zhang Y, Liu Y, Wu Y, et al. Blockade of Tim-3 signaling restores the virus-specific CD8? T-cell response in patients with chronic hepatitis B. Eur J Immunol. 2012;42:1180-91 pubmed publisher
Ivie S, Fennessey C, Sheng J, Rubin D, McClain M. Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ?-toxin. PLoS ONE. 2011;6:e17787 pubmed publisher
Vega Carrascal I, Reeves E, Niki T, Arikawa T, McNally P, O Neill S, et al. Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. J Immunol. 2011;186:2897-909 pubmed publisher

product information

brand :

R&D Systems

master code :

2365-TM

SKU :

2365-TM-050

product name :

Recombinant Human TIM-3 Fc Chimera Protein, CF

description :

The Recombinant Human TIM-3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TIM-3 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

TIM-3

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

66 kDa, reducing conditions

theoretical molecular weight :

46.4 kDa (monomer)

gene symbol :

HAVCR2

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Galectin-9 (Catalog # 2045-GA ) at 500 ng/mL can bind Recombinant Human TIM-3 Fc Chimera with an apparent Kd 30 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q8TDQ0

applications :

Binding Activity

source :

NS0-derived Recombinant Human TIM-3 Fc Chimera Protein, CF

USD :

399

USD 2023 :

405 USD

alt names :

CD366, FLJ14428, HAVcr-2, HAVCR2, hepatitis A virus cellular receptor 2, kidney injury molecule-3, KIM-3, SPTCL, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain-containing protein 3, TIM 3, Tim-3, TIM3, TIM3 T-cell membrane protein 3, TIMD3, TIMD-3, TIMD3KIM-3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage