Recombinant Human IL-36 gamma/IL-1F9 Protein | R&D Systems 2320-IL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-36 gamma/IL-1F9 Protein

catalog :

2320-IL

quantity :

25 ug

price :

329 USD

citations: 6

Reference
Guo J, Tu J, Hu Y, Song G, Yin Z. Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis. Drug Des Devel Ther. 2019;13:581-588 pubmed publisher
Lacy S, Wu C, Ambrosi D, Hsieh C, Bose S, Miller R, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1Î± and IL-1Î². MAbs. 2015;7:605-19 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Carrier Y, Ma H, Ramon H, Napierata L, Small C, O Toole M, et al. Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis. J Invest Dermatol. 2011;131:2428-37 pubmed publisher
Johnston A, Xing X, Guzman A, Riblett M, Loyd C, Ward N, et al. IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 2011;186:2613-22 pubmed publisher
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, et al. S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell. 2008;19:78-85 pubmed

product information

brand :

R&D Systems

master code :

2320-IL

SKU :

2320-IL-025

product name :

Recombinant Human IL-36 gamma/IL-1F9 Protein

description :

The Recombinant Human IL-36 gamma/IL-1F9 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-36 gamma/IL-1F9 Protein has been validated for the following applications: Binding Activity.

target :

IL-36 gamma/IL-1F9

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and TCEP with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

18.7 kDa

gene symbol :

IL36G

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL-36 gamma at 1 µg/mL (100 µL/well) can bind recombinant human IL-1 Rrp2 Fc Chimera (Catalog # 872-RP) with a linear range of 0.15 - 5 µg/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

2320-IL

accessionNumbers :

Q9NZH8

applications :

Binding Activity

source :

E. coli -derived human IL-36 gamma/IL-1F9 protein Met1-Asp169

extended description :

A New rh IL-36g is Available! It has ~1000 fold better activity and lower endotoxin specification!

2020 USD :

329

2021 USD :

329 USD

product details :

A New rh IL-36g is Available! It has ~1000 fold better activity and lower endotoxin specification!

alt names :

IL-1 epsilon, IL-1 H1, IL-1 Related Protein 2, IL-1(EPSILON), IL1E, IL-1-epsilon, IL1F9, IL-1F9, IL1H1, IL-1H1, IL-1-Related Protein 2, IL1RP2, IL-1RP2, IL36 gamma, IL36G, interleukin 1 family, member 9, interleukin 1-related protein 2, Interleukin 36, Gamma, Interleukin-1 epsilon, interleukin-1 family member 9, Interleukin-1 homolog 1, Interleukin-36 Gamma

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.