Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein | R&D Systems 232-FA product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein

catalog :

232-FA

quantity :

25 ug

price :

179 USD

citations: 18

Reference
Woolston A, Khan K, Spain G, Barber L, Griffiths B, Gonzalez Exposito R, et al. Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Cancer Cell. 2019;36:35-50.e9 pubmed publisher
Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci Rep. 2019;9:3713 pubmed publisher
Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:730-746.e6 pubmed publisher
Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, et al. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat Med. 2015;21:530-6 pubmed publisher
Tucker B, Mullins R, Streb L, Anfinson K, Eyestone M, Kaalberg E, et al. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. elife. 2013;2:e00824 pubmed publisher
Luo X, Hutley L, Webster J, Kim Y, Liu D, Newell F, et al. Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Diabetes. 2012;61:124-36 pubmed publisher
Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher
Darby S, Murphy T, Thomas H, Robson C, Leung H, Mathers M, et al. Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease. Br J Cancer. 2009;101:1891-9 pubmed publisher
Zhang P, Nelson S, Bagby G, Siggins R, Shellito J, Welsh D. The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells. 2008;26:1778-86 pubmed publisher
Patel V, Likar K, Zisman Rozen S, Cowherd S, Lassiter K, Sher I, et al. Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J Biol Chem. 2008;283:9308-17 pubmed publisher
Patel V, Knox S, Likar K, Lathrop C, Hossain R, Eftekhari S, et al. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007;134:4177-86 pubmed
Lin B, Wang M, Blackmore C, Desnoyers L. Liver-specific activities of FGF19 require Klotho beta. J Biol Chem. 2007;282:27277-84 pubmed
Baharvand H, Hashemi S, Kazemi Ashtiani S, Farrokhi A. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol. 2006;50:645-52 pubmed
Masih Khan E, Trudel S, Heise C, Li Z, Paterson J, Nadeem V, et al. MIP-1alpha (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma. Blood. 2006;108:3465-71 pubmed
Shin J, Min M, Larrieu Lahargue F, Canron X, Kunstfeld R, Nguyen L, et al. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006;17:576-84 pubmed
Steinberg Z, Myers C, Heim V, Lathrop C, Rebustini I, Stewart J, et al. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development. 2005;132:1223-34 pubmed
Ohashi K, Waugh J, Dake M, Yokoyama T, Kuge H, Nakajima Y, et al. Liver tissue engineering at extrahepatic sites in mice as a potential new therapy for genetic liver diseases. Hepatology. 2005;41:132-40 pubmed
Dame M, Yu X, Garrido R, Bobrowski W, McDuffie J, Murphy H, et al. A stepwise method for the isolation of endothelial cells and smooth muscle cells from individual canine coronary arteries. In Vitro Cell Dev Biol Anim. 2003;39:402-6 pubmed

product information

brand :

R&D Systems

master code :

232-FA

SKU :

232-FA-025

product name :

Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein

description :

The Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein from R&D Systems is derived from E. coli. The Recombinant Human FGF acidic/FGF1 (aa 16-155) Protein has been validated for the following applications: Bioactivity.

target :

FGF acidic/FGF1

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4 and EDTA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

15.5 kDa

gene symbol :

FGF1

details of functionality :

Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Rizzino, A. et al . (1988) Cancer Res. 48 :4266; Thomas, K. et al . (1987) Methods Enzymol. 147 :120. The ED50 for this effect is 0.015-0.15 ng/mL in the presence of 10 µg/mL of heparin.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

232-FA

accessionNumbers :

NP_000791

applications :

Bioactivity

source :

E. coli -derived human FGF acidic/FGF1 protein Phe16-Asp155, with an N-terminal Met

2020 USD :

179

2021 USD :

179 USD

alt names :

AFGF, alpha, alpha-ECGF, beta-ECGF, ECGF, ECGFB, ECGF-betaAcidic fibroblast growth factor, endothelial cell growth factor, beta, FGF acidic, FGF-1, FGFABeta-endothelial cell growth factor, FGF-alpha, fibroblast growth factor 1 (acidic), GLIO703, HBGF1, HBGF-1, heparin-binding growth factor 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.