Recombinant Human LAG-3 Fc Chimera Protein, CF | R&D Systems 2319-L3 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human LAG-3 Fc Chimera Protein, CF

catalog :

2319-L3

quantity :

50 ug

price :

349 USD

citations: 3

Reference
Lecocq Q, Zeven K, De Vlaeminck Y, Martens S, Massa S, Goyvaerts C, et al. Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use. Biomolecules. 2019;9: pubmed publisher
Weinberg A, Canniff J, Rouphael N, Mehta A, Mulligan M, Whitaker J, et al. Varicella-Zoster Virus-Specific Cellular Immune Responses to the Live Attenuated Zoster Vaccine in Young and Older Adults. J Immunol. 2017;199:604-612 pubmed publisher
Tian X, Zhang A, Qiu C, Wang W, Yang Y, Qiu C, et al. The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. J Immunol. 2015;194:3873-82 pubmed publisher

product information

brand :

R&D Systems

master code :

2319-L3

SKU :

2319-L3-050

product name :

Recombinant Human LAG-3 Fc Chimera Protein, CF

description :

The Recombinant Human LAG-3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human LAG-3 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

LAG-3

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

90 kDa, reducing conditions

theoretical molecular weight :

72.7 kDa (monomer)

gene symbol :

LAG3

details of functionality :

Measured by its ability to induce TNF-alpha secretion by JAWSII mouse immature dendritic cells. The ED50 for this effect is 1-4 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

2319-L3

accessionNumbers :

P18627

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human LAG-3 protein Human LAG-3 (Leu23-Leu450) Accession # P18627 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

349

2021 USD :

349 USD

alt names :

CD223, CD223 antigen, LAG3, LAG-3, lymphocyte activating 3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, Secreted lymphocyte activation gene 3 protein, sLAG-3

storage :

12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.