product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human B7-H3 (4Ig)/B7-H3b Protein, CF
catalog :
2318-B3-050/CF
quantity :
50 ug (also 1 mg)
price :
468 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Li H, Yang Z, Yang X, Zhang F, Wang J, Wu Z, et al. LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma. Cell Death Dis. 2022;13:109 pubmed publisher
Yoon B, Chung Y, Yoo S, Kawara K, Kim J, Yoo I, et al. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis. J Biol Chem. 2016;291:4048-57 pubmed publisher
product information
brand :
R&D Systems
master code :
2318-B3/CF
SKU :
2318-B3-050/CF
product name :
Recombinant Human B7-H3 (4Ig)/B7-H3b Protein, CF
unit size :
50 ug (also 1 mg)
seo description :
The Recombinant Human B7-H3 (4Ig)/B7-H3b Protein, CF from R&D Systems is derived from NS0. The Recombinant Human B7-H3 (4Ig)/B7-H3b Protein, CF has been validated for the following applications: Bioactivity.
target :
B7-H3
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
78-90 kDa, reducing conditions
theoretical molecular weight :
48 kDa
gene symbol :
CD276
details of functionality :
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells. T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with 500 ng/mL anti-CD3 and/or 10 ╡g/mL rhB7-H3 (4Ig)/B7-H3b. The presence of rhB7-H3 (4Ig)/B7-H3b at 10 ╡g/mL inhibited the anti-CD3 response by 30%. Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q5ZPR3
applications :
Bioactivity
source :
NS0-derived Recombinant Human B7-H3 (4Ig)/B7-H3b Protein, CF
USD :
468 USD
alt names :
B7H3, B7H34Ig-B7-H3, B7-H3B7 homolog 3, CD276, CD276 antigen, CD276 molecule, Costimulatory molecule
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.