Recombinant Mouse Crossveinless-2 Protein | R&D Systems 2299-CV-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Crossveinless-2 Protein

catalog :

2299-CV-050

quantity :

50 ug

price :

578 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Lockyer P, Mao H, Fan Q, Li L, Yu Lee L, Eissa N, et al. LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation. Arterioscler Thromb Vasc Biol. 2017;37:1524-1535 pubmed publisher
Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, et al. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009;184:597-609 pubmed publisher
Ambrosio A, Taelman V, Lee H, Metzinger C, Coffinier C, De Robertis E. Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. Dev Cell. 2008;15:248-60 pubmed publisher

product information

master code :

2299-CV

SKU :

2299-CV-050

product name :

Recombinant Mouse Crossveinless-2 Protein

unit size :

50 ug

description :

The Recombinant Mouse Crossveinless-2 Protein from R&D Systems is derived from NS0. The Recombinant Mouse Crossveinless-2 Protein has been validated for the following applications: Bioactivity.

target :

Crossveinless-2/CV-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

36-39 kDa and 50-55 kDa, reducing conditions

gene symbol :

Bmper

details of functionality :

Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al . (2004) Biochem. Biophys. Res. Commun. 315 :272. The ED50 for this effect is 0.5-2 ╡g/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAH66153

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse Crossveinless-2/CV-2 protein Val34-Arg685, with an N-terminal 9-His tag, Ala39-Asp369 & Pro370-Arg685

source short :

NS0

USD :

578 USD

alt names :

BMP binding endothelial regulator, BMP-binding endothelial regulator precursor protein, BMP-binding endothelial regulator protein, BMPER, Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, CRIM3, crossveinless 2, crossveinless-2, Cv2, CV-2, hCV2, KIAA1965, Protein crossveinless-2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage