Recombinant Mouse Siglec-2/CD22 Fc Chimera Protein, CF | R&D Systems 2296-SL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Siglec-2/CD22 Fc Chimera Protein, CF

catalog :

2296-SL-050

quantity :

50 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Lee M, Kiefel H, LaJevic M, Macauley M, Kawashima H, O Hara E, et al. Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing. Nat Immunol. 2014;15:982-95 pubmed publisher

product information

brand :

R&D Systems

master code :

2296-SL

SKU :

2296-SL-050

product name :

Recombinant Mouse Siglec-2/CD22 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Mouse Siglec-2/CD22 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Siglec-2/CD22 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-2/CD22

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

140-150 kDa, reducing conditions

theoretical molecular weight :

103 kDa (monomer)

gene symbol :

Cd22

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 0.08-0.4 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P35329

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse Siglec-2/CD22 Fc Chimera Protein, CF

USD :

456 USD

alt names :

B-cell receptor CD22, BL-CAM, B-lymphocyte cell adhesion molecule, CD22, CD22 antigenMGC130020, CD22 molecule, sialic acid binding Ig-like lectin 2, Sialic acid-binding Ig-like lectin 2, Siglec2, SIGLEC-2, SIGLEC2FLJ22814, T-cell surface antigen Leu-14

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage