Recombinant Human 4-1BB Ligand/TNFSF9 Protein, CF | R&D Systems 2295-4L-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human 4-1BB Ligand/TNFSF9 Protein, CF

catalog :

2295-4L-025/CF

quantity :

25 ug

price :

345 USD

citations: 5

Reference
Chin S, Kimberlin C, Roe Zurz Z, Zhang P, XU A, Liao Chan S, et al. Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. Nat Commun. 2018;9:4679 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Madireddi S, Eun S, Lee S, Nemčovičová I, Mehta A, Zajonc D, et al. Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med. 2014;211:1433-48 pubmed publisher
Moh M, Lorenzini P, Gullo C, Schwarz H. Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB J. 2013;27:2957-66 pubmed publisher
Lobito A, Ramani S, Tom I, Bazan J, Luis E, Fairbrother W, et al. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. J Biol Chem. 2011;286:18969-81 pubmed publisher

product information

master code :

2295-4L/CF

SKU :

2295-4L-025/CF

product name :

Recombinant Human 4-1BB Ligand/TNFSF9 Protein, CF

unit size :

25 ug

description :

The Recombinant Human 4-1BB Ligand/TNFSF9 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human 4-1BB Ligand/TNFSF9 Protein, CF has been validated for the following applications: Binding Activity.

target :

4-1BB Ligand/TNFSF9

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS, NaCl and PEG and with Trehalose.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

theoretical molecular weight :

20.4 kDa

gene symbol :

TNFSF9

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human (rh) 4-1BB/TNFRSF9/CD137 Fc Chimera (Catalog # 838-4B ) is Immobilized at 10 ng/mL (100 ╡L/well), the concentration of rh4-1BB Ligand that produces 50% optimal binding response is found to be approximately 0.5-2.5 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P41273.1

applications :

Binding Activity

source long :

E. coli -derived human 4-1BB Ligand/TNFSF9 protein Arg71-Glu254, with an N-terminal Met and a 6-His tag

source short :

E. coli

USD :

345 USD

alt names :

4-1BB ligand, 41BB Ligand, 4-1BBL, 4-1BB-L, CD137L, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, TNFSF9, tumor necrosis factor (ligand) superfamily, member 9, tumor necrosis factor ligand superfamily member 9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 3 months, 2 to 8 ░C under sterile conditions after reconstitution.