Recombinant Human gp130 Protein | R&D Systems 228-GP-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human gp130 Protein

catalog :

228-GP-010

quantity :

10 ug (also 50 ug)

price :

385 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Okuyama Y, Tanaka Y, Jiang J, Kamimura D, Nakamura A, Ota M, et al. Bmi1 Regulates I?B? Degradation via Association with the SCF Complex. J Immunol. 2018;: pubmed publisher
Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, et al. Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression. Cancer Res. 2017;77:2279-2291 pubmed publisher
Adams R, Burnley R, Valenzano C, Qureshi O, Doyle C, Lumb S, et al. Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep. 2017;7:37716 pubmed publisher
Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T. IL-6 trans-signaling is another pathway to upregulate Osteopontin. Cytokine. 2017;90:88-95 pubmed publisher
König C, Morch E, Eitner A, Möller C, Turnquist B, Schaible H, et al. Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha. J Neurosci. 2016;36:9782-91 pubmed publisher
Meng J, Jiang J, Atsumi T, Bando H, Okuyama Y, Sabharwal L, et al. Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II. J Immunol. 2016;197:3111-3119 pubmed
Cho S, Pirih F, Koh A, Michalski M, Eber M, Ritchie K, et al. The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone. J Biol Chem. 2013;288:6814-25 pubmed publisher
Chollangi S, Mather T, Rodgers K, Ash J. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012;287:32848-59 pubmed
Ahmed S, Marotte H, Kwan K, Ruth J, Campbell P, Rabquer B, et al. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci U S A. 2008;105:14692-7 pubmed publisher
Richards P, Nowell M, Horiuchi S, McLoughlin R, Fielding C, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 2006;54:1662-72 pubmed
Erices A, Conget P, Rojas C, Minguell J. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24-32 pubmed
Hurst S, Wilkinson T, McLoughlin R, Jones S, Horiuchi S, Yamamoto N, et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity. 2001;14:705-14 pubmed

product information

brand :

R&D Systems

master code :

228-GP

SKU :

228-GP-010

product name :

Recombinant Human gp130 Protein

unit size :

10 ug (also 50 ug)

seo description :

The Recombinant Human gp130 Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human gp130 Protein has been validated for the following applications: Bioactivity.

target :

gp130

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

theoretical molecular weight :

68 kDa

gene symbol :

IL6ST

details of functionality :

Measured by its ability to inhibit IL-6-dependent proliferation of the 7TD1 mouse hybridoma cells in the presence of Recombinant Human IL-6 R alpha (Catalog # 227-SR ). The ED50 for this effect is 1.00-12.0 ╡g/mL in the presence of 4 ╡g/mL recombinant human (rh) IL-6 R alpha and 25 pg/mL rhIL-6.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P40189

applications :

Bioactivity

source :

Sf 21 (baculovirus)-derived Recombinant Human gp130 Protein

USD :

385 USD

alt names :

CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage