Recombinant Human NKp44 Fc Chimera Protein, CF | R&D Systems 2249-NK-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human NKp44 Fc Chimera Protein, CF

catalog :

2249-NK-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 15

Reference
Murayama Y, Kasahara Y, Kubo N, Shin C, Imamura M, Oike N, et al. NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma. Transl Oncol. 2022;25:101521 pubmed publisher
Lim S, Moon Y, Shin M, Kim T, Chae S, Yee C, et al. Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways. Cancers (Basel). 2021;13: pubmed publisher
Tremblay McLean A, Coenraads S, Kiani Z, Dupuy F, Bernard N. Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function. BMC Immunol. 2019;20:8 pubmed publisher
Gross C, Schulte Mecklenbeck A, RÃ¼nzi A, Kuhlmann T, Posevitz FejfÃ¡r A, Schwab N, et al. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A. 2016;113:E2973-82 pubmed publisher
Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, HÃ¼bscher D, et al. Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1. PLoS ONE. 2015;10:e0125544 pubmed publisher
Mou X, Zhou Y, Jiang P, Zhou T, Jiang Q, Xu C, et al. The regulatory effect of UL-16 binding protein-3 expression on the cytotoxicity of NK cells in cancer patients. Sci Rep. 2014;4:6138 pubmed publisher
Robinet P, Baychelier F, Fontaine T, Picard C, Debre P, Vieillard V, et al. A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells. J Immunol. 2014;192:5332-42 pubmed publisher
Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, et al. Human cytomegalovirus infection elicits new decidual natural killer cell effector functions. PLoS Pathog. 2013;9:e1003257 pubmed publisher
Varchetta S, Brunetta E, Roberto A, Mikulak J, Hudspeth K, Mondelli M, et al. Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. PLoS ONE. 2012;7:e45821 pubmed publisher
Bellucci R, Nguyen H, Martin A, Heinrichs S, Schinzel A, Hahn W, et al. Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. J Clin Invest. 2012;122:2369-83 pubmed publisher
MADRID A, Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol. 2012;86:8693-704 pubmed publisher
Esin S, Batoni G, Counoupas C, Stringaro A, Brancatisano F, Colone M, et al. Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria. Infect Immun. 2008;76:1719-27 pubmed publisher
Shi J, Tricot G, Garg T, Malaviarachchi P, Szmania S, Kellum R, et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood. 2008;111:1309-17 pubmed
Banerjee P, Feuer G, Barker E. Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the. J Virol. 2007;81:9707-17 pubmed
Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, et al. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood. 2007;110:1207-14 pubmed

product information

brand :

R&D Systems

master code :

2249-NK

SKU :

2249-NK-050

product name :

Recombinant Human NKp44 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human NKp44 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human NKp44 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

NKp44/NCR2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

61-67 kDa, reducing conditions

theoretical molecular weight :

45 kDa (monomer)

gene symbol :

NCR2

details of functionality :

Measured by its ability to bind HeLa human cervical epithelial carcinoma cells in a flow cytometry assay. When 400 ng of rhNKp44 Fc chimera is added to 2 x 105 Hela cells, 25% cells bind to the protein.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

CAB31968.1

applications :

Bioactivity

source :

NS0-derived Recombinant Human NKp44 Fc Chimera Protein, CF

USD :

432 USD

alt names :

CD336, CD336 antigen, LY95, LY95lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44), lymphocyte antigen 95 (activating NK-receptor; NK-p44), Lymphocyte antigen 95 homolog, natural cytotoxicity triggering receptor 2, Natural killer cell p44-related protein, NCR2, NK cell activating receptor (NKp44), NK cell-activating receptor, NKP44, NK-p44dJ149M18.1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage