Recombinant Human Cadherin-12 (CAD-12) Fc Chimera, CF | R&D Systems 2240-CA-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cadherin-12 (CAD-12) Fc Chimera, CF

catalog :

2240-CA-050

quantity :

50 ug

price :

523 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Suzuki H, Nagase S, Saito C, Takatsuka A, Nagata M, Honda K, et al. Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models. Mol Cancer Ther. 2024;23:257-271 pubmed publisher
Oldak L, Lukaszewski Z, Le x15b niewska A, Go x142 awski K, Lauda x144 ski P, Gorodkiewicz E. Development of an SPRi Test for the Quantitative Detection of Cadherin 12 in Human Plasma and Peritoneal Fluid. Int J Mol Sci. 2023;24: pubmed publisher
Chu K, Cheng C, Ye X, Lee Y, Zurita A, Chen D, et al. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res. 2008;6:1259-67 pubmed publisher

product information

brand :

R&D Systems

master code :

2240-CA

SKU :

2240-CA-050

product name :

Recombinant Human Cadherin-12 (CAD-12) Fc Chimera, CF

unit size :

50 ug

seo description :

The Recombinant Human Cadherin-12 (CAD-12) Fc Chimera, CF from R&D Systems is derived from NS0. The Recombinant Human Cadherin-12 (CAD-12) Fc Chimera, CF has been validated for the following applications: Bioactivity.

target :

Cadherin-12

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris-Citrate, NaCl and CaCl2.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

115 kDa, reducing conditions

theoretical molecular weight :

92.5 kDa (monomer)

gene symbol :

CDH12

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of Caki-2 human clear cell carcinoma epithelial cells. When 5 x 104 cells/well are added to Recombinant Human Pro-Cadherin-12 Fc Chimera coated plates (5 ╡g/mL with 100 ╡L/well), approximately 30% will adhere after 30 minutes at 37 ░C. Optimal concentration depends on cell type as well as the application or research objectives.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P55289

applications :

Bioactivity

source :

NS0-derived Recombinant Human Cadherin-12 (CAD-12) Fc Chimera, CF

USD :

523 USD

alt names :

BR-cadherin, cadherin 12, type 2 (N-cadherin 2), cadherin-12, Cadherin12, CDH12, CDHB, FLJ34857, N-Cadherin 2, Neural type cadherin 2, neural type, 2, neuronal cadherin 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage