Recombinant Human CD25/IL-2R alpha Protein | R&D Systems 223-2A-005 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CD25/IL-2R alpha Protein

catalog :

223-2A-005

quantity :

5 ug (also 25 ug)

price :

234 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Sahin D, Arenas Ramirez N, Rath M, Karakus U, Hümbelin M, van Gogh M, et al. An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer. Nat Commun. 2020;11:6440 pubmed publisher
Ganguly B, Balasa B, Efros L, Hinton P, Hartman S, Thakur A, et al. The CD25-binding antibody Daclizumab High-Yield Process has a distinct glycosylation pattern and reduced antibody-dependent cell-mediated cytotoxicity in comparison to ZenapaxÂ®. MAbs. 2016;8:1417-1424 pubmed
Akoum A, Al Akoum M, Lemay A, Maheux R, Leboeuf M. Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain. Fertil Steril. 2008;89:1618-24 pubmed

product information

brand :

R&D Systems

master code :

223-2A

SKU :

223-2A-005

product name :

Recombinant Human CD25/IL-2R alpha Protein

unit size :

5 ug (also 25 ug)

seo description :

The Recombinant Human CD25/IL-2R alpha Protein from R&D Systems is derived from NS0. The Recombinant Human CD25/IL-2R alpha Protein has been validated for the following applications: Bioactivity.

target :

CD25/IL-2R alpha

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

36 kDa, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

IL2RA

details of functionality :

Measured by its ability to inhibit the IL-2-dependent proliferation of MO7e human megakaryocytic leukemic cells. Avanzi, G. et al . (1988) Br. J. Haematol. 69 :359. The ED50 for this effect is 0.15-0.75 ╡g/mL in the presence of 30 ng/mL of recombinant human IL-2.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P01589

applications :

Bioactivity

source :

NS0-derived Recombinant Human CD25/IL-2R alpha Protein

USD :

234 USD

alt names :

CD25, CD25 antigen, IDDM10, IL-2 R alpha, IL-2 receptor subunit alpha, IL2R, IL2R alpha, IL-2R subunit alpha, IL-2Ra, IL2RA, IL-2-RA, IL2-RA, interleukin 2 receptor, alpha, interleukin-2 receptor subunit alpha, p55, TAC antigen, TCGFR

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage